轻度认知障碍患者脑脊液总Tau蛋白与β42淀粉样蛋白的Meta分析

发布时间：2018-11-17 10:01

【摘要】：目的采用Meta分析方法研究轻度认知障碍(mild cognitive impairment,MCI)患者脑脊液总tau(totaltau,T-tau)蛋白及β淀粉样蛋白42(β-amyloid 42,Aβ42)水平的改变。方法计算机检索Pubmed、Cochrane临床试验数据库,Ovid全文电子期刊、中国知网全文数据库、维普中文期刊数据库及万方等数据库中关于MCI患者中脑脊液T-tau蛋白及Aβ42变化的病例-对照研究,采用Review Manager 5.2软件对数据进行Meta分析。结果共有17篇文献纳入分析。Meta分析结果显MCI患者脑脊液中T-tau蛋白水平显著高于对照组(MD=113.10,95%CI=87.93~138.26);而脑脊液中Aβ42水平明显低于正常对照组(MD=-146.50,95%CI=-178.70~-114.29),且两者的改变均有统计学差异(P0.01)。结论 MCI患者脑脊液T-tau蛋白水平明显增高,而Aβ42水平明显下降。
[Abstract]:Objective to study the changes of total tau (totaltau,T-tau) and 尾 -amyloid 42 (尾-amyloid 42 A 尾 42) levels in cerebrospinal fluid (CSF) of patients with mild cognitive impairment (mild cognitive impairment,MCI) by Meta analysis. Methods Pubmed,Cochrane clinical trial database, Ovid full text electronic journal and full text database were searched by computer. A case-control study on the changes of cerebrospinal fluid (T-tau) protein and A 尾 _ (42) in cerebrospinal fluid (CSF) in patients with MCI was carried out in Weipu Chinese Journal Database and Wanfang database. Review Manager 5.2 software was used to analyze the data by Meta. Results 17 articles were included in the analysis. The results of Meta analysis showed that the level of T-tau protein in cerebrospinal fluid of MCI patients was significantly higher than that of control group (MD=113.10,95%CI=87.93~138.26). The level of A 尾 42 in cerebrospinal fluid was significantly lower than that in normal control group (MD=-146.50,95%CI=-178.70~-114.29), and there was significant difference between the two groups (P0.01). Conclusion the level of T-tau protein in cerebrospinal fluid (CSF) of patients with MCI was significantly increased, while the level of A 尾 42 was significantly decreased.
【作者单位】：苏州大学附属第二医院神经内科;
【分类号】：R749.1

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