重复经颅磁刺激对老年抑郁症患者临床症状及自杀意念的疗效

发布时间：2018-11-18 20:55

【摘要】：目的探讨重复经颅磁刺激对老年抑郁症患者临床症状及自杀意念的疗效。方法将178例老年抑郁症有自杀意念的患者随机分为两组,研究组80例,对照组98例,两组均给予常规药物治疗,研究组在常规药物治疗的基础上联合重复经颅磁刺激治疗,每周5次,2周为1个疗程,治疗4周。分别于治疗前、治疗2周、治疗4周后采用汉密尔顿抑郁量表(HAMD)和自杀意念自评量表(SIOSS)对治疗效果进行评分。治疗2周后减分率≥20%为显效,治疗4周后减分率≥25%为有效。结果(1)两组患者在年龄、性别、民族、职业、婚姻状况、受教育程度等方面比较均无统计学差异(P0.05);(2)两组患者治疗前HAMD评分及SIOSS评分无统计学差异(P0.05),治疗后两组的评分均有不同程度的降低,但研究组更显著(P0.05);(3)研究组在治疗2周后显效率明显高于对照组,两组比较有显著的统计学意义(52.5%vs 28.6%;χ2=10.569,P0.01);研究组治疗4周后的有效率明显高于对照组,两组比较有显著的统计学意义(77.5%vs 53.1%;χ2=15.470,P0.05)。结论重复经颅磁刺激能缩短起效时间,改善老年抑郁症患者的临床症状,首先改善患者睡眠质量,随治疗时间的延长,认识障碍、躯体化症状、迟缓等状况也明显改善,并且能减轻老年抑郁症患者的自杀意念,降低自杀风险。
[Abstract]:Objective to investigate the effect of repeated transcranial magnetic stimulation (TMS) on clinical symptoms and suicidal ideation in elderly patients with depression. Methods 178 elderly patients with suicidal ideation were randomly divided into two groups: study group (n = 80) and control group (n = 98). Five times a week, 2 weeks as a course of treatment for 4 weeks. Hamilton Depression scale (HAMD) and suicide Ideation scale (SIOSS) were used to evaluate the therapeutic effect before, 2 weeks and 4 weeks respectively. After 2 weeks treatment, the score reduction rate 鈮，

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