孤独谱系障碍治疗前后血清性激素水平研究

发布时间：2018-11-21 15:35

【摘要】：目的探讨孤独谱系障碍(autism spectrum disorder,ASD)患者在治疗后症状改善的情况下,血清卵泡刺激素(follicle-stimulating hormone,FSH)、黄体生成素(luteotropic hormone,LH)、雌二醇(estradiol,E2)、孕酮和睾酮水平的变化情况。方法入组21例月龄为(62.19±18.84)月的ASD患者和30名月龄为(64.40±7.48)月的正常发育儿童(对照组)。孤独谱系障碍患者入组后用心理教育评定量表中文修订版(Chinese version of psycho-education profile-revised,C-PEP)评估其发育水平,并测定血清性激素水平,所有患者均接受康复训练,同时合并经颅磁刺激(repetitive transcranial magnetic stimulation,r TMS)治疗,6个月后复查C-PEP和血清性激素水平。对照组进行一次性激素检测。结果 ASD组患者在治疗后C-PEP总分的提高有统计学意义(P0.001)。治疗前,ASD组与对照组血清FSH、LH水平的差异无统计学意义(P0.05),而ASD组E2、孕酮和睾酮水平较高(P0.001);治疗6个月后,ASD组与对照组血清FSH、LH水平的差异无统计学意义(均P0.05),而ASD组E2、孕酮和睾酮水平较对照组高(P0.001)。与治疗前相比较,ASD组在治疗后血清各性激素浓度的改变无统计学意义(均P0.05)。结论 ASD患者的血清E2、孕酮、睾酮浓度升高,且不随症状改变而变化,提示ASD患者血清E2、孕酮、睾酮水平可能具有状态独立性。
[Abstract]:Objective to investigate the changes of serum follicle stimulating hormone (follicle-stimulating hormone,FSH), luteinizing hormone (luteotropic hormone,LH) and estradiol (estradiol,E2) in patients with solitary lineage disorder (autism spectrum disorder,ASD). Changes in progesterone and testosterone levels. Methods 21 ASD patients (62.19 卤18.84) months old and 30 normal developmental children (64.40 卤7.48) months old (control group) were enrolled. The patients with lonely pedigree disorder were assessed their developmental level and serum sex hormone level by (Chinese version of psycho-education profile-revised,C-PEP. All the patients received rehabilitation training. Combined with transcranial magnetic stimulation (repetitive transcranial magnetic stimulation,r TMS), C-PEP and serum sex hormone levels were examined 6 months later. The control group was tested for sex hormone. Results the total score of C-PEP in ASD group was significantly higher than that in control group (P0. 001). Before treatment, there was no significant difference in serum FSH,LH levels between ASD group and control group (P0.05), while the levels of E2, progesterone and testosterone were higher in ASD group (P0.001). After 6 months of treatment, there was no significant difference in serum FSH,LH levels between ASD group and control group (P0.05), while the levels of E2, progesterone and testosterone in ASD group were higher than those in control group (P0.001). Compared with before treatment, there was no significant change in serum sex hormone concentration after treatment in ASD group (P0.05). Conclusion the serum levels of E2, progesterone and testosterone in patients with ASD are elevated and do not change with the change of symptoms, suggesting that the serum levels of E2, progesterone and testosterone in patients with ASD may have state independence.
【作者单位】：深圳市康宁医院儿少精神科;深圳市精神卫生中心;深圳市脑神经发育障碍康复技术工程实验室;
【基金】：深圳市科技创新委员会资助项目(编号:JCYJ20120829150246-301)(编号:JCYJ20140415092628039) 深圳市卫生计生系统科研项目(编号:201402093)
【分类号】：R749.94

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