基于张量的形态学测量在轻度认知障碍患者大脑灰质萎缩诊断中的价值

发布时间：2018-11-26 09:00

【摘要】：目的探索轻度认知障碍患者的大脑灰质结构萎缩的规律,区分不同轻度认知障碍亚型的灰质结构萎缩模式的异同。方法数据来自阿尔茨海默病的神经影像(Alzheimer’s disease neuroimaging initiative,ADNI)数据库,包括34例正常人、22例稳定性轻度认知障碍和20例进展性轻度认知障碍患者60个月纵向高分辨MRI 3D T1W结构像。基于张量的形态学(tensor-based morphology,TBM)测量方法进行数据分析,利用DARTEL配准过程中得到的雅克比矩阵计算出行列式的值和迹,并对得到的特征参数进行组内方差分析,然后采用多重比较的配对t检验,获取相对首次扫描时间点时不同跟踪时间点大脑灰质萎缩的规律及特征。结果采用两种参数得到的结果相对一致,3组被试数据均表现为随着时间的推移,大脑灰质萎缩区域逐步扩大,萎缩程度逐步增加,尤其对于颞叶、额叶、海马和扣带回等与认知相关的区域萎缩最为明显。但是在相同时间点,相对于正常组来说,稳定型的轻度认知障碍患者组大脑灰质萎缩程度较为严重,进展型的轻度认知障碍患者组大脑灰质萎缩最为严重。结论 TBM测量法得到的大脑灰质萎缩差异可以用于区分稳定性、进展性轻度认知障碍以及正常人大脑结构,可指导阿尔茨海默病的早期诊断和相关临床干预。
[Abstract]:Objective to explore the pattern of gray matter structure atrophy in patients with mild cognitive impairment and to distinguish the different patterns of gray matter structure atrophy in different subtypes of mild cognitive impairment. Methods data were obtained from the neuroimaging (Alzheimer's disease neuroimaging initiative,ADNI database of Alzheimer's disease, including 34 normal subjects. In 22 patients with stable mild cognitive impairment and 20 patients with progressive mild cognitive impairment, longitudinal high resolution MRI 3D T1W structural images were observed at 60 months. Based on Zhang Liang's morphology (tensor-based morphology,TBM) measurement method, the data are analyzed, and the value and trace of determinant are calculated by using the Jacobian matrix obtained in the course of DARTEL registration, and the intra-group variance analysis of the obtained characteristic parameters is carried out. Then the rule and characteristics of gray matter atrophy at different tracking time points at different time points of the first scan were obtained by using the paired t test of multiple comparisons. Results the results obtained by using the two parameters were relatively consistent. The data of the three groups showed that with the passage of time, the area of gray matter atrophy gradually expanded and the degree of atrophy gradually increased, especially for temporal lobe and frontal lobe. Hippocampal and cingulate gyrus and other cognitive-related areas of atrophy is the most obvious. But at the same time, compared with the normal group, the gray matter atrophy was more serious in the stable mild cognitive impairment group, and the most serious in the progressive mild cognitive impairment group. Conclusion the difference of gray matter atrophy obtained by TBM can be used to distinguish stability, progressive mild cognitive impairment and normal brain structure, which can be used to guide the early diagnosis of Alzheimer's disease and related clinical intervention.
【作者单位】：首都医科大学附属北京天坛医院医学工程处;
【分类号】：R445.2;R749

【相似文献】