男性酒依赖患者戒断期前瞻记忆研究
发布时间：2018-12-06 21:31
【摘要】：目的研究男性酒依赖患者戒断期基于事件前瞻记忆(EBPM)和基于时间前瞻记忆(TBPM)的特征，明确基于事件前瞻记忆(EBPM)和基于时间前瞻记忆(TBPM)在男性酒依赖患者中的损害情况，探讨前瞻记忆与临床特征的关系，并对前瞻记忆与执行功能的关系进行分析。 方法选取32例男性酒依赖患者和30名年龄、受教育程度与酒依赖组相匹配的正常对照者，排除标准包括：神经系统疾病者，既往有脑外伤病史及精神疾病史，严重躯体疾病及其他精神活性物质滥用者，进行前瞻记忆测试及与前额叶功能相关的执行功能实验。 结果患者组的EBPM评分[(3.91±0.69)分]和TBPM评分[(3.28±0.77)分]，与正常对照组[EBPM：(4.47±0.63)分、TBPM：(4.20±0.66)分]相比，差异有统计学意义(t=-3.348，P0.0l；t=-5.032，P0.0l)。患者组在数字广度实验的顺向测试（t=-2.580，P=0.012）和反向测试成绩均低于对照组（t=-5.032，P=0.005），，数字符号得分低于对照（t=-5.327，P＜0.001）。与对照组相比，酒依赖患者Stroop色词测验C部分反应时（41.70±7.37）长于对照组（33.33±6.64,P0.001)、正确阅读数（21.13±1.74）低于对照组（22.47±1.28,P0.01)；B部分反应时（22.10±4.03）长于对照组（19.30±3.18,P0.01)，正确阅读数差异无统计学意义(P0.05)。A部分反应时、正确阅读数差异均无统计学意义(P0.05)，与对照组相比，酒依赖患者干扰效应（19.62±6.97）高于对照组（13.70±5.69）(P0.01)。 相关分析显示，患者EBPM评分、TBPM评分与饮酒时间、成瘾时间、日饮酒量、数字广度、数字符号无显著相关性，与戒断时间呈正相关（r=0.444，P0.05;r=0.423，P0.05）,TBPM评分与Stroop色词测试呈负相关（r=-0.479，P0.01）。 结论男性酒依赖患者戒断期基于事件前瞻记忆和基于时间前瞻记忆均存在损害，患者戒断期执行功能存在损害，前瞻记忆与其戒断时间存在相关性，基于时间前瞻记忆与Stroop实验中冲突抑制能力和Stroop效应呈负相关，因此，前额叶损害可能是戒断期患者前瞻记忆损害的神经机制之一。
[Abstract]:Objective to study the characteristics of event-based prospective memory (EBPM) and time-based prospective memory (TBPM) in male patients with alcohol dependence. To explore the relationship between prospective memory and clinical features and to analyze the relationship between prospective memory and executive function in male patients with alcohol dependence by determining the damage of event-based prospective memory (EBPM) and time-based prospective memory (TBPM). Methods 32 male patients with alcohol dependence and 30 healthy controls with education level matched with alcohol dependence group were selected. The exclusion criteria included: nervous system disease, previous history of brain trauma and mental illness. Patients with severe somatic diseases and other psychoactive substance abusers were tested for prospective memory and executive function related to prefrontal function. Results the scores of EBPM [(3.91 卤0.69)] and TBPM [(3.28 卤0.77)] in the patients group were compared with those in the control group [EBPM: (4.47 卤0.63), TBPM: (4.20 卤0.66]. The difference was statistically significant (t = 3.348, P 0.0l). T0. 01- 5. 032g. P 0. 0l). The scores of forward test and reverse test in the digital span test were lower than those in the control group (t = -5.032, P < 0.005), and the scores of digital symbols were lower than those in the control group (t = -5.327, P < 0.001). Compared with the control group, the C part reaction time of Stroop color words test in the patients with alcohol dependence was (41.70 卤7.37) longer than that in the control group (33.33 卤6.64 P0.001), and the correct reading number was (21.13 卤1.74) lower than that in the control group (22.47 卤1.28 P0.01). Part B reaction time (22.10 卤4.03) was longer than that of control group (19.30 卤3.18 P0.01), and there was no significant difference in correct reading number (P0.05). Compared with the control group, the interference effect of the patients with alcohol dependence (19.62 卤6.97) was higher than that of the control group (13.70 卤5.69) (P0.01). Correlation analysis showed that there was no significant correlation between EBPM score, TBPM score and drinking time, addiction time, daily alcohol consumption, digital span, digital symbol, but positively correlated with withdrawal time (r = 0.444p 0.05). There was a negative correlation between Stroop color word test and), TBPM score (r = 0.423, P 0.01). Conclusion both event-based prospective memory and time-based prospective memory are impaired in the male patients with alcohol dependence, and the executive function of the patients is impaired during the withdrawal period, and prospective memory is correlated with the withdrawal time. Temporal prospective memory is negatively correlated with the ability of conflict inhibition and Stroop effect in Stroop experiment. Therefore, prefrontal lobe damage may be one of the neural mechanisms of prospective memory impairment in abstinent patients.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.62
本文编号：2366692
[Abstract]:Objective to study the characteristics of event-based prospective memory (EBPM) and time-based prospective memory (TBPM) in male patients with alcohol dependence. To explore the relationship between prospective memory and clinical features and to analyze the relationship between prospective memory and executive function in male patients with alcohol dependence by determining the damage of event-based prospective memory (EBPM) and time-based prospective memory (TBPM). Methods 32 male patients with alcohol dependence and 30 healthy controls with education level matched with alcohol dependence group were selected. The exclusion criteria included: nervous system disease, previous history of brain trauma and mental illness. Patients with severe somatic diseases and other psychoactive substance abusers were tested for prospective memory and executive function related to prefrontal function. Results the scores of EBPM [(3.91 卤0.69)] and TBPM [(3.28 卤0.77)] in the patients group were compared with those in the control group [EBPM: (4.47 卤0.63), TBPM: (4.20 卤0.66]. The difference was statistically significant (t = 3.348, P 0.0l). T0. 01- 5. 032g. P 0. 0l). The scores of forward test and reverse test in the digital span test were lower than those in the control group (t = -5.032, P < 0.005), and the scores of digital symbols were lower than those in the control group (t = -5.327, P < 0.001). Compared with the control group, the C part reaction time of Stroop color words test in the patients with alcohol dependence was (41.70 卤7.37) longer than that in the control group (33.33 卤6.64 P0.001), and the correct reading number was (21.13 卤1.74) lower than that in the control group (22.47 卤1.28 P0.01). Part B reaction time (22.10 卤4.03) was longer than that of control group (19.30 卤3.18 P0.01), and there was no significant difference in correct reading number (P0.05). Compared with the control group, the interference effect of the patients with alcohol dependence (19.62 卤6.97) was higher than that of the control group (13.70 卤5.69) (P0.01). Correlation analysis showed that there was no significant correlation between EBPM score, TBPM score and drinking time, addiction time, daily alcohol consumption, digital span, digital symbol, but positively correlated with withdrawal time (r = 0.444p 0.05). There was a negative correlation between Stroop color word test and), TBPM score (r = 0.423, P 0.01). Conclusion both event-based prospective memory and time-based prospective memory are impaired in the male patients with alcohol dependence, and the executive function of the patients is impaired during the withdrawal period, and prospective memory is correlated with the withdrawal time. Temporal prospective memory is negatively correlated with the ability of conflict inhibition and Stroop effect in Stroop experiment. Therefore, prefrontal lobe damage may be one of the neural mechanisms of prospective memory impairment in abstinent patients.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.62
【共引文献】
相关博士学位论文 前1条
1 周艳艳;海洛因戒除者的执行功能：药物相关线索与负性情绪线索启动的影响[D];浙江大学;2012年
相关硕士学位论文 前1条
1 刘刚;男性酒精依赖患者威斯康星卡片分类测验与质子波谱动态研究[D];南京医科大学;2008年
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