三维动脉自旋标记技术评价阿尔茨海默病患者脑血流灌注

发布时间：2018-12-07 06:51

【摘要】：目的观察阿尔茨海默病(AD)患者全脑三维(3D)伪连续动脉自旋标记(3DpcASL)成像中脑血流灌注(CBF)特点,分析其与认知功能评分的相关性。方法对16例AD患者(AD组)和19例年龄匹配的认知功能正常者(对照组)进行常规MR和3DpcASL灌注成像。使用SPM 8软件对所获脑血流图进行预处理,比较两组CBF差异,评价CBF减低脑区CBF值与MMSE、MoCA评分的相关性。结果 AD组CBF灌注减低区主要见于双侧颞上回、颞中回、颞下回、双侧楔前叶、双侧中扣带回、后扣带回、左侧角回、左侧顶下回及左侧额上回(t=5.32,P0.001);双侧楔前叶、双侧中后扣带回、双侧颞上回、左侧颞中回、左侧颞下回、左侧角回及左侧顶下回CBF值与MMSE、MoCA评分呈正相关(P0.05)。结论3DpcASL可发现AD患者脑区灌注异常,灌注减低区的CBF值与认知功能减低存在相关性。
[Abstract]:Objective to observe the characteristics of cerebral blood flow perfusion (CBF) in three-dimensional (3D) pseudo-continuous arterial spin labeling (3DpcASL) imaging of patients with Alzheimer's disease (AD), and to analyze its correlation with cognitive function score. Methods conventional MR and 3DpcASL perfusion imaging were performed in 16 patients with AD (AD group) and 19 age-matched patients with normal cognitive function (control group). The SPM 8 software was used to pretreat the obtained cerebral blood flow map, and the difference of CBF between the two groups was compared, and the correlation between the CBF value of the reduced brain area of CBF and the MMSE,MoCA score was evaluated. Results in AD group, the areas of decreased CBF perfusion were mainly found in bilateral superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus, bilateral precuneal lobe, bilateral middle cingulate gyrus, posterior cingulate gyrus, left angular gyrus, left inferior parietal gyrus and left superior frontal gyrus (t = 5.32, P0.001). The CBF values of bilateral anterior cuneate lobe, bilateral posterior cingulate gyrus, bilateral superior temporal gyrus, left middle temporal gyrus, left inferior temporal gyrus, left angular gyrus and left inferior parietal gyrus were positively correlated with MMSE,MoCA score (P0.05). Conclusion 3DpcASL can find abnormal cerebral perfusion in AD patients. The CBF value in hypoperfusion area is correlated with cognitive impairment.
【作者单位】：北京大学第三医院放射科;北京大学第三医院神经内科;
【分类号】：R749.1;R445.2

【参考文献】