IL-10基因启动子多态性与强迫症关系

发布时间：2018-12-11 18:41

【摘要】：目的探讨白细胞介素-10(IL-10)基因启动子多态性与强迫症(OCD)的关系。方法 381例OCD患者和485名健康对照为研究对象,通过聚合酶链式反应与限制性片段长度多态性(PCR-RFLP)基因分型技术对IL-10基因标签单核酸多态性(SNP)位点592A/C(rs1800872)、1082A/G(rs1800896)、819T/C(rs1800871)进行基因分型;以耶鲁-布朗强迫量表(Y-BOCS)评定OCD患者的病情。结果 OCD组和对照组IL-10基因rs1800872、rs1800896、rs1800871位点在基因型频率分布与等位基因频率分布差异均无统计学意义(P0.05);不同发病年龄女性3个SNPs OCD组与对照组人群基因型与等位基因频率分布无明显差异(P0.05);男性rs1800896基因型(χ2=6.51,P=0.039)和等位基因(χ2=6.59,P=0.01,OR=1.84,95%CI=1.15~2.95)频率分布在OCD组与对照组之间存在差异;OCD组男女性别之间rs1800896基因型(χ2=8.08,P=0.02)和等位基因(χ2=6.97,P=0.008,OR=1.95,95%CI=1.18~3.23)频率分布也存在差异。结论 IL-10基因(rs1800896)可能与男性OCD易感性有关。
[Abstract]:Objective to investigate the relationship between interleukin-10 (IL-10) gene promoter polymorphism and obsessive-compulsive disorder (OCD) (OCD). Methods 381 patients with OCD and 485 healthy controls were enrolled in this study. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (PCR-RFLP) genotyping techniques were used to detect 592A/C (rs1800872) at the (SNP) locus of single nucleic acid polymorphism in IL-10. 1082A/G (rs1800896) and 819T/C (rs1800871) were genotyped. Yale-Brown obsessive-compulsive scale (Y-BOCS) was used to evaluate the condition of OCD patients. Results there was no significant difference in genotype frequency distribution and allele frequency distribution between OCD group and control group (P0.05). There was no significant difference in the frequency distribution of genotype and allele between the three SNPs OCD groups and the control group (P0.05). The frequency distribution of rs1800896 genotype (蠂 2 + 6.51) and allele (蠂 2 + 6.59) in male (蠂 2 / 6.59) was 1.84 / 95 / 1.152.95) between the OCD group and the control group, there was a significant difference in the frequency distribution between the two groups. There were also differences in the frequency distribution of rs1800896 genotype and allele between male and female in OCD group (蠂 2 + 8.08) and allele (蠂 2 + 6.97). Conclusion IL-10 gene (rs1800896) may be associated with male OCD susceptibility.
【作者单位】：滨州市优抚医院精神科;青岛大学医学院附属医院;青岛大学医学院;
【分类号】：R749.7

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