劲动脉狭窄与认知功能障碍及血清超敏C反应蛋白的相关性研究
发布时间：2018-12-12 04:18
【摘要】：目的:研究颈动脉狭窄与认知功能障碍及血清超敏C反应蛋白的相关性。方法:采用彩色多普勒血管超声将67例颈动脉狭窄患者分为颈动脉轻度狭窄组(n=22例,动脉血管内径缩小30%)、颈动脉中度狭窄组(n=25例,动脉血管内径缩小30%~70%)和颈动脉重度狭窄组(n=20例,动脉血管内径缩小70%)。同期选取25例无颈动脉狭窄门诊正常体检者作为对照组。采用简易精神状态量表(MMSE)和Mo CA检测颈动脉轻度狭窄组、颈动脉中度狭窄组、颈动脉重度狭窄组患者认知功能;采用酶联免疫吸附(ELISA)法检测颈动脉轻度狭窄组、颈动脉中度狭窄组、颈动脉重度狭窄组患者及对照组血清hs-CRP表达水平;根据Mo CA将颈动脉狭窄患者分为认知功能障碍组及非认知功能障碍组,采用ELISA法检测两组患者血清hs-CRP表达水平。结果:1中度狭窄组患者MMSE评分、定向力、即刻回忆力及延迟回忆力均明显低于轻度狭窄组(P0.05),而重度狭窄组患者MMSE评分、定向力、即刻回忆力及延迟回忆力均明显低于中度狭窄组(P0.05),各组颈动脉狭窄组患者在语言能力及注意计算力等方面比较无显著差异性(P0.05);2中度狭窄组患者Mo CA总分、视空间与执行功能、延迟回忆、定向力等均明显低于轻度狭窄组(P0.05),而重度狭窄组患者Mo CA总分、视空间与执行功能、延迟回忆、定向力等均明显低于中度狭窄组(P0.05),各组颈动脉狭窄组患者在命名、注意力、语言、抽象等方面比较无显著差异性(P0.05);3各组狭窄组患者血清hs-CRP表达水平均明显高于对照组(P0.05),且随颈动脉狭窄程度加重患者血清hs-CRP表达水平明显升高(P0.05);4 67例颈动脉狭窄患者经Mo CA评分共分为认知功能障碍组(n=37例)与非认知功能障碍组(n=30例),认知功能障碍组患者血清hs-CRP表达水平明显高于非认知功能障碍组(P0.05);5 MMSE评分及Mo CA评分与颈动脉狭窄程度呈负相关性关系(r1=-0.374,r2=-0.365,P0.05),血清hs-CRP表达水平与颈动脉狭窄程度呈正相关性关系(r3=0.402,P0.05)。结论:颈动脉狭窄与认知功能障碍及hs-CRP呈正相关性关系。颈动脉狭窄程度越重,认知功能障碍损害越明显;颈动脉狭窄程度越重,血清hs-CRP表达水平越高;认知功能障碍越重,血清hs-CRP表达水平越高。
[Abstract]:Objective: to study the relationship between carotid artery stenosis and cognitive impairment and serum hypersensitive C reactive protein. Methods: 67 patients with carotid artery stenosis were divided into two groups by color Doppler ultrasound: mild carotid stenosis group (n = 22), carotid artery stenosis group (n = 25), carotid artery stenosis group (n = 22) and carotid artery stenosis group (n = 25). The arterial diameter was reduced by 30% (70%) and in the group of severe carotid stenosis (n = 20, the diameter of artery was reduced by 70%). At the same time, 25 normal subjects without carotid artery stenosis were selected as control group. The cognitive function of patients with mild stenosis of carotid artery, moderate stenosis of carotid artery and severe stenosis of carotid artery were measured by (MMSE) and Mo CA. The expression of serum hs-CRP in patients with mild stenosis of carotid artery, moderate stenosis of carotid artery, severe stenosis of carotid artery and control group were detected by enzyme-linked immunosorbent assay (ELISA). According to Mo CA, the patients with carotid artery stenosis were divided into two groups: cognitive dysfunction group and non-cognitive dysfunction group. The expression of serum hs-CRP was detected by ELISA method. Results: 1the MMSE score, orientation, immediate recall and delayed recall in moderate stenosis group were significantly lower than those in mild stenosis group (P0.05), while MMSE score and orientation in severe stenosis group were significantly lower than those in mild stenosis group. Immediate recall and delayed recall were significantly lower than those of moderate stenosis group (P0.05). There was no significant difference in language ability and attention computing ability in carotid artery stenosis group (P0.05). 2the total score of Mo CA, visual space and executive function, delayed recall, orientation in moderate stenosis group were significantly lower than those in mild stenosis group (P0.05), while Mo CA total score, visual space and executive function, delayed recall in severe stenosis group were significantly lower than those in mild stenosis group (P0.05). Orientation was significantly lower than that in moderate stenosis group (P0.05). There was no significant difference in naming, attention, language, abstraction and other aspects in carotid artery stenosis group (P0.05). 3The expression of serum hs-CRP in the patients with stenosis was significantly higher than that in the control group (P0.05), and the expression of serum hs-CRP was significantly increased with the severity of carotid artery stenosis (P0.05). 467 patients with carotid artery stenosis were divided into cognitive dysfunction group (n = 37) and non-cognitive dysfunction group (n = 30) by Mo CA score. The level of serum hs-CRP expression in patients with cognitive dysfunction was significantly higher than that in patients without cognitive dysfunction (P0.05). 5 there was a negative correlation between MMSE score and Mo CA score and the degree of carotid artery stenosis (R1 + -0.374). The expression of hs-CRP in serum was positively correlated with the degree of carotid stenosis (R3n0.402) (P0.05). Conclusion: carotid stenosis is positively correlated with cognitive impairment and hs-CRP. The more severe the carotid artery stenosis, the more obvious the cognitive impairment; the more severe the carotid artery stenosis, the higher the level of serum hs-CRP expression; the more serious the cognitive dysfunction, the higher the level of serum hs-CRP expression.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R749.1
本文编号：2373889
[Abstract]:Objective: to study the relationship between carotid artery stenosis and cognitive impairment and serum hypersensitive C reactive protein. Methods: 67 patients with carotid artery stenosis were divided into two groups by color Doppler ultrasound: mild carotid stenosis group (n = 22), carotid artery stenosis group (n = 25), carotid artery stenosis group (n = 22) and carotid artery stenosis group (n = 25). The arterial diameter was reduced by 30% (70%) and in the group of severe carotid stenosis (n = 20, the diameter of artery was reduced by 70%). At the same time, 25 normal subjects without carotid artery stenosis were selected as control group. The cognitive function of patients with mild stenosis of carotid artery, moderate stenosis of carotid artery and severe stenosis of carotid artery were measured by (MMSE) and Mo CA. The expression of serum hs-CRP in patients with mild stenosis of carotid artery, moderate stenosis of carotid artery, severe stenosis of carotid artery and control group were detected by enzyme-linked immunosorbent assay (ELISA). According to Mo CA, the patients with carotid artery stenosis were divided into two groups: cognitive dysfunction group and non-cognitive dysfunction group. The expression of serum hs-CRP was detected by ELISA method. Results: 1the MMSE score, orientation, immediate recall and delayed recall in moderate stenosis group were significantly lower than those in mild stenosis group (P0.05), while MMSE score and orientation in severe stenosis group were significantly lower than those in mild stenosis group. Immediate recall and delayed recall were significantly lower than those of moderate stenosis group (P0.05). There was no significant difference in language ability and attention computing ability in carotid artery stenosis group (P0.05). 2the total score of Mo CA, visual space and executive function, delayed recall, orientation in moderate stenosis group were significantly lower than those in mild stenosis group (P0.05), while Mo CA total score, visual space and executive function, delayed recall in severe stenosis group were significantly lower than those in mild stenosis group (P0.05). Orientation was significantly lower than that in moderate stenosis group (P0.05). There was no significant difference in naming, attention, language, abstraction and other aspects in carotid artery stenosis group (P0.05). 3The expression of serum hs-CRP in the patients with stenosis was significantly higher than that in the control group (P0.05), and the expression of serum hs-CRP was significantly increased with the severity of carotid artery stenosis (P0.05). 467 patients with carotid artery stenosis were divided into cognitive dysfunction group (n = 37) and non-cognitive dysfunction group (n = 30) by Mo CA score. The level of serum hs-CRP expression in patients with cognitive dysfunction was significantly higher than that in patients without cognitive dysfunction (P0.05). 5 there was a negative correlation between MMSE score and Mo CA score and the degree of carotid artery stenosis (R1 + -0.374). The expression of hs-CRP in serum was positively correlated with the degree of carotid stenosis (R3n0.402) (P0.05). Conclusion: carotid stenosis is positively correlated with cognitive impairment and hs-CRP. The more severe the carotid artery stenosis, the more obvious the cognitive impairment; the more severe the carotid artery stenosis, the higher the level of serum hs-CRP expression; the more serious the cognitive dysfunction, the higher the level of serum hs-CRP expression.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R749.1
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