塞来昔布对颅脑外伤患者认知功能障碍的改善作用观察

发布时间：2018-12-15 09:19

【摘要】：目的观察塞来昔布对颅脑外伤患者认知功能障碍的改善作用。方法将76例颅脑外伤患者随机分为观察组(38例)和对照组(38例),两组给予相同的常规治疗,治疗组同时给予塞来昔布。塞来昔布治疗前后,采用简明精神状态量表(MMSE)和蒙特利尔量表(Mo CA)评分评定患者认知功能和疗效,采用Barthel指数(BI)评分评定患者的生活质量。结果治疗组治疗后MMSE和Mo CA评分均较治疗前和同期对照组明显升高(P均0.05);治疗组认知功能总改善率(94.73%)明显高于对照组(78.94%),两组相比,P0.05;治疗组随访3个月BI评分均较治疗前及同期对照组显著增高(P均0.05)。结论塞来昔布可有效改善颅脑外伤患者的认知功能障碍,同时患者生活质量也得到明显改善。
[Abstract]:Objective to observe the effect of celecoxib on cognitive dysfunction in patients with craniocerebral trauma. Methods 76 patients with craniocerebral trauma were randomly divided into observation group (n = 38) and control group (n = 38). The two groups were given the same routine treatment and the treatment group were given celecoxib at the same time. Before and after celecoxib treatment, the cognitive function and curative effect were evaluated by (MMSE) and (Mo CA), and the quality of life was evaluated by Barthel (BI). Results the scores of MMSE and Mo CA in the treatment group were significantly higher than those in the control group before and in the same period (P 0.05), the total improvement rate of cognitive function in the treatment group (94.73%) was significantly higher than that in the control group (78.94%), and there was a significant difference between the two groups (P 0.05). The BI scores in the treatment group were significantly higher than those in the control group after 3 months follow-up (P < 0. 05). Conclusion Celecoxib can effectively improve the cognitive function of patients with craniocerebral trauma and the quality of life.
【作者单位】：邢台医学高等专科学校;
【基金】：河北省自然科学基金资助项目(C2004000689) 河北省博士基金资助项目(05547008D-4) 河北省科学技术与社会发展计划项目(04276135)
【分类号】：R749.12

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