阿尔茨海默病患者外周血炎症因子水平与认知功能的相关性研究

发布时间：2018-12-18 02:05

【摘要】：目的探讨阿尔茨海默病(AD)患者血清中炎症因子IL-6、IL-1β、TNF-α、IFN-γ水平及其与认知功能的相关性。方法纳入AD患者110例,以及年龄、性别匹配的认知功能正常的对照人群120例。搜集受试者的一般资料和疾病信息。采用简易精神状态量表(MMSE)和临床痴呆评定量表(CDR)对受试者认知功能和日常行为能力进行评估。收集血清,采用ELISA法测定血清炎症因子IL-6、IL-1β、TNF-α和IFN-γ的浓度。比较两组血清炎症因子水平的差异,采用非条件logistic回归筛选AD可能的影响因素。以全部人群为研究对象,分析血清炎症因子水平与MMSE评分的相关性。以AD组为研究对象,分析患者血清炎症因子水平与CDR评分的相关性。结果 AD组血清中IL-1β(秩均值129.46pg/ml vs 102.70pg/ml,P=0.002)、IL-6(秩均值125.25pg/ml vs 106.56pg/ml,P=0.033)水平显著高于对照组,但TNF-α(秩均值116.40pg/ml vs 114.67pg/ml,P=0.844)和IFN-γ(秩均值115.90pg/ml vs 115.14pg/ml,P=0.931)水平与对照组相比差异无统计学意义。整体人群中,仅IL-1β水平与MMSE评分呈负相关(r=-0.184,P=0.007)。AD患者血清中各炎症因子水平与CDR评分无相关性。危险因素分析显示,IL-1β是罹患AD的危险因素(OR=1.018,95%CI 1.005~1.030),受教育年限为保护性因素(OR=0.891,95%CI 0.834~0.953)。结论血清炎症因子水平与整体人群的认知功能相关,但与AD患者的痴呆严重度无明显相关性。
[Abstract]:Objective to investigate the levels of inflammatory cytokines IL-6,IL-1 尾, TNF- 伪, IFN- 纬 in serum of patients with Alzheimer's disease (AD) and their correlation with cognitive function. Methods 110 patients with AD and 120 subjects with normal cognitive function matched by age and sex were included. Collect general information and disease information about the subjects. Simple mental state scale (MMSE) and clinical dementia scale (CDR) were used to evaluate the cognitive function and daily behavior ability of the subjects. Serum levels of IL-6,IL-1 尾, TNF- 伪 and IFN- 纬 were determined by ELISA method. The difference of serum inflammatory factor levels between the two groups was compared, and the possible influencing factors of AD were screened by non-conditional logistic regression. The correlation between serum inflammatory factor level and MMSE score was analyzed. The correlation between serum inflammatory factor level and CDR score was analyzed in AD group. Results the serum levels of IL-1 尾 (129.46pg/ml vs 102.70 PG / ml P0. 002) and IL-6 (125.25pg/ml vs 106.56 PG / ml P0. 033) in the AD group were significantly higher than those in the control group. However, the levels of TNF- 伪 (rank mean 116.40pg/ml vs 114.67 PG / ml) and IFN- 纬 (rank mean 115.90pg/ml vs 115.14 PG / ml P0. 931) were not significantly different from those of the control group. In the whole population, only the level of IL-1 尾 was negatively correlated with the MMSE score (r = -0.184). AD, P < 0. 007). There was no correlation between the level of serum inflammatory factors and the CDR score. The analysis of risk factors showed that IL-1 尾 was the risk factor of AD (OR=1.018,95%CI 1.005n 1.030), and the length of education was the protective factor (OR=0.891,95%CI 0.834 卤0.953). Conclusion the level of serum inflammatory factors is correlated with the cognitive function of the whole population, but not with the severity of dementia in patients with AD.
【作者单位】：第三军医大学大坪医院野战外科研究所神经内科;
【基金】：国家自然科学基金(30973144、81270423) 重庆市杰出青年科学基金(CSTC 2010BA5004) 中国博士后科学基金(2013T60955) 重庆市博士后科研项目(Xm201342)~~
【分类号】：R749.16

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