NR3C1基因多态性及单倍型、父母教养方式对青少年焦虑障碍的影响

发布时间：2018-12-23 08:58

【摘要】：NR3C1参与HPA轴调节,与应激相关的身心疾病关系密切。以往针对NR3C1与焦虑障碍的研究基本以成人为考察对象,且大多关注负性生活事件等个体层面环境变量。本研究采用病例-对照设计,以238名青少年为被试(焦虑障碍117人,对照121人),旨在考察NR3C1常见位点rs6191、rs6196、rs41423247的多态性、单倍型以及父母不同类型教养方式对焦虑障碍的影响。结果表明rs6191 GG基因型、rs6196 AA基因型、rs41423247 GG基因型与低焦虑障碍风险相关。父母过多的过度保护与冷漠拒绝、父亲过少的温暖关怀可预测较高的焦虑障碍风险。rs41423247多态性与母亲温暖关怀存在交互作用:rs41423247 GG基因型只在母亲温暖关怀较多时能降低焦虑障碍风险,在母亲温暖关怀较少时与焦虑障碍并无显著相关。此外,rs6191-rs6196-rs41423247构成的单倍型GAG与低焦虑障碍风险显著关联,TGC与高焦虑障碍风险显著关联,且二者与母亲温暖关怀、母亲过度保护分别存在交互作用。未来可采用追踪研究,从表观遗传层面探讨教养方式与NR3C1影响焦虑障碍的内在机制。
[Abstract]:NR3C1 participates in the regulation of HPA axis and is closely related to stress-related physical and mental diseases. Previous studies on NR3C1 and anxiety disorders have focused on adults and most of them focused on negative life events and other individual environmental variables. A case-control study was conducted in 238 adolescents (117 with anxiety disorder and 121 as control) to investigate the polymorphism of rs6191,rs6196,rs41423247 at common loci of NR3C1. The effects of haplotypes and different parenting styles on anxiety disorder. The results showed that rs6191 GG genotype, rs6196 AA genotype and rs41423247 GG genotype were associated with low anxiety disorder risk. Too much protection and indifference from parents, The higher risk of anxiety disorder could be predicted by too little warm care of father. There was interaction between rs41423247 polymorphism and warm care of mother: rs41423247 GG genotype could reduce the risk of anxiety disorder only when the mother had more warm care. There was no significant correlation between anxiety disorder and maternal warmth. In addition, the haplotype GAG composed of rs6191-rs6196-rs41423247 was significantly associated with the risk of low anxiety disorder, and TGC was significantly associated with the risk of high anxiety disorder, and there was interaction between the haplotype GAG and the mother's warm care and mother's overprotection, respectively. In the future, tracing research can be used to explore the relationship between upbringing style and the internal mechanism of NR3C1 affecting anxiety disorder from the epigenetic level.
【作者单位】：华南师范大学心理学院/华南师范大学心理应用研究中心;华南师范大学特殊教育学院;
【基金】：国家自然科学基金面上项目(31271096,31671165) 国家社会科学基金重大项目(14ZDB159) 教育部人文社会科学重点研究基地重大项目(16JJD190001) 广东省高等学校珠江学者岗位计划资助项目(2016) 中国博士后科学基金面上资助项目(2015M580724)与特别资助项目(2016T90790)
【分类号】：R749.72

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