复方菖蒲益智颗粒口服辅助治疗血管性认知功能障碍效果观察
发布时间：2018-12-31 12:13
【摘要】：目的观察复方菖蒲益智颗粒剂口服辅助治疗血管性认知功能障碍(VCI)的效果,及其对血清胰岛素样生长因子1(IGF-1)、一氧化氮(NO)和内皮素1(ET-1)水平的影响。方法将102例VCI患者随机分为观察组和对照组各51例。两组均给予西药口服治疗(尼莫地平,奥拉西坦胶囊),观察组加服复方菖蒲益智颗粒,治疗6个月。比较两组治疗前后认知功能、日常生活能力(ADL)、中医证候积分,检测治疗前后血清IGF-1、NO和ET-1。结果治疗第3、6个月时,两组认知功能MMSE、MoCA评分均高于同组治疗前(P均0.05),ADL评分、中医证候积分低于同组治疗前(P均0.05);观察组治疗第6个月MMSE、MoCA评分均高于对照组而ADL评分低于对照组,第3、6个月中医证候积分均低于对照组,差异有统计学意义(P均0.05)。治疗第6个月两组血清IGF-1、NO水平均高于同组治疗前,ET-1水平低于同组治疗前,差异有统计学意义(P均0.05);观察组治疗第6个月血清IGF-1、NO水平高于对照组,血清ET-1水平低于对照组,差异有统计学意义(P均0.05)。结论在常规西药治疗基础上辅助应用复方菖蒲益智颗粒治疗VCI,可升高血清IGF-1、NO水平而降低ET-1水平,提高临床疗效。
[Abstract]:Objective to observe the efficacy of compound Acorus Yizhi granules in the treatment of vascular cognitive dysfunction (VCI) and its effect on serum insulin-like growth factor 1 (IGF-1). Effects of nitric oxide (NO) and endothelin 1 (ET-1) levels. Methods 102 patients with VCI were randomly divided into two groups: the observation group (n = 51) and the control group (n = 51). Both groups were treated with western medicine orally (nimodipine, olaxetam capsule), and the observation group with compound Acorus Yizhi granules for 6 months. To compare the scores of TCM syndromes of cognitive function and daily living ability of (ADL), before and after treatment between the two groups, and to detect serum IGF-1,NO and ET-1. before and after treatment. Results at the 3rd and 6th month after treatment, the MMSE,MoCA scores of cognitive function in the two groups were higher than those in the same group before treatment (all P 0. 05), ADL), and the scores of TCM syndromes were lower than those of the same group before treatment (all P 0. 05). The MMSE,MoCA score of the observation group was higher than that of the control group at the 6th month and the ADL score was lower than that of the control group. The scores of TCM syndromes in the 3rd and 6th months were lower than those in the control group (P < 0. 05). At the 6th month after treatment, the serum IGF-1,NO levels of the two groups were higher than those of the same group before treatment, and the level of ET-1 was lower than that of the same group before treatment (P < 0. 05). The serum IGF-1,NO level and serum ET-1 level in the observation group were significantly higher than those in the control group at the 6th month after treatment (P < 0. 05). Conclusion the treatment of VCI, with compound Acorus Yizhi granules on the basis of routine western medicine treatment can increase the level of serum IGF-1,NO, decrease the level of ET-1, and improve the clinical efficacy.
【作者单位】： 河北省中医院;沧州中西医结合医院;晋州市人民医院;
【基金】：河北省科技计划项目(15277748D) 河北省中医药类重大医学科研课题(zyzd2013004)
【分类号】：R749.13
，
本文编号：2396560
[Abstract]:Objective to observe the efficacy of compound Acorus Yizhi granules in the treatment of vascular cognitive dysfunction (VCI) and its effect on serum insulin-like growth factor 1 (IGF-1). Effects of nitric oxide (NO) and endothelin 1 (ET-1) levels. Methods 102 patients with VCI were randomly divided into two groups: the observation group (n = 51) and the control group (n = 51). Both groups were treated with western medicine orally (nimodipine, olaxetam capsule), and the observation group with compound Acorus Yizhi granules for 6 months. To compare the scores of TCM syndromes of cognitive function and daily living ability of (ADL), before and after treatment between the two groups, and to detect serum IGF-1,NO and ET-1. before and after treatment. Results at the 3rd and 6th month after treatment, the MMSE,MoCA scores of cognitive function in the two groups were higher than those in the same group before treatment (all P 0. 05), ADL), and the scores of TCM syndromes were lower than those of the same group before treatment (all P 0. 05). The MMSE,MoCA score of the observation group was higher than that of the control group at the 6th month and the ADL score was lower than that of the control group. The scores of TCM syndromes in the 3rd and 6th months were lower than those in the control group (P < 0. 05). At the 6th month after treatment, the serum IGF-1,NO levels of the two groups were higher than those of the same group before treatment, and the level of ET-1 was lower than that of the same group before treatment (P < 0. 05). The serum IGF-1,NO level and serum ET-1 level in the observation group were significantly higher than those in the control group at the 6th month after treatment (P < 0. 05). Conclusion the treatment of VCI, with compound Acorus Yizhi granules on the basis of routine western medicine treatment can increase the level of serum IGF-1,NO, decrease the level of ET-1, and improve the clinical efficacy.
【作者单位】： 河北省中医院;沧州中西医结合医院;晋州市人民医院;
【基金】：河北省科技计划项目(15277748D) 河北省中医药类重大医学科研课题(zyzd2013004)
【分类号】：R749.13
，
本文编号：2396560
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