地黄益脑胶囊治疗血管性痴呆的临床研究

发布时间：2019-01-04 18:07

【摘要】：目的：观察地黄益脑胶囊治疗肾虚血瘀型血管性痴呆的临床疗效。方法：本课题临床研究采用单盲,随机对照试验,通过样本估算确定样本含量为60例,随机分为地黄益脑胶囊治疗组40例,口服地黄益脑胶囊(熟地黄、生地黄、淮山药、蔓荆子、枸杞子、茯苓、黄精、玉竹、决明子、川芎、山茱萸、当归、夜交滕、酸枣仁、丹皮、炙甘草)治疗,对照组20例口服脑复康治疗。疗程为2个月。本研究对比了两组药物的临床总疗效,选择了MMSE,HDS和FAQ量表进行神经心理、认知能力的检测,观察治疗前后血液流变学指标变化和药物的毒副反应,对比治疗前后中医症状的改变,分析地黄益脑胶囊对血管性痴呆疗效和患者年龄的相关性。结果：地黄益脑胶囊对肾虚血瘀型血管性痴呆的患者有肯定的疗效,益智作用明显,总有效率达77.5%,脑复康对照组总有效率50.00%,经统计学处理,两组有显著性差异(P0.05)。且对中医症状的改善效果优于对照组,尤其是腰膝酸软,耳鸣耳聋,尿后余沥或失禁,肢体麻木,判断力减退,识别力减退,计算力减退,人格障碍以及舌脉更明显(P0.01,P0.05),经过MMSE,HDS和FAQ量表神经心理、认知能力的检测,结果治疗后HDS、FAQ和MMSE积分值均有改善,但治疗组效果更明显(P0.01)且治疗组MMSE积分明显高于对照组(P0.05),对血液流变的作用,治疗组治疗后各项指标均有显著改善(P0.01,P0.05),而对照组治疗前后均无明显差异,可见地黄益脑胶囊具有良好的活血化瘀作用。地黄益脑胶囊治疗血管性痴呆的疗效和患者年龄无关,广泛适用于51-82岁之间的老年前期及老年期患者,其疗效和脑血管疾病分期有关,对脑血管病早期的痴呆疗效更好。通过对该药的急性毒性和长期毒性实验观察,未发现毒副反应。结论：地黄益脑胶囊治疗肾虚血瘀型血管性痴呆疗效确切。
[Abstract]:Objective: to observe the clinical effect of Dihuang Yinao capsule on vascular dementia with kidney deficiency and blood stasis. Methods: a single blind, randomized controlled trial was used to determine the sample size of 60 cases. The patients were randomly divided into treatment group (40 cases) treated with Rehmannia yinao capsule (Rehmannia glutinosa), Rehmannia glutinosa (Rehmannia glutinosa), Chinese yam (Dioscorea sinensis). Vitex chinensis, Fructus Lycii, Poria cocos, Yellow extract, Yudu, Cassia seed, Ligusticum chuanxiong, Cornus officinalis, Angelica sinensis, Niangjiao Teng, Zizyphus jujuba, Cortex Salvia, Radix Glycyrrhiza) were treated. The course of treatment was 2 months. In this study, we compared the total clinical efficacy of the two groups of drugs, selected MMSE,HDS and FAQ scale to test the neuropsychological and cognitive ability, observed the changes of hemorheology indexes and side effects of the drugs before and after treatment. To compare the changes of TCM symptoms before and after treatment, and to analyze the correlation between the curative effect of Dihuang Yinao capsule on vascular dementia and the age of the patients. Results: Dihuang Yinao capsule had definite curative effect on vascular dementia with kidney deficiency and blood stasis type. The total effective rate was 77.5%, and the total effective rate was 77.5%. The total effective rate of Naofukang control group was 50.00g, which was treated by statistics. There was significant difference between the two groups (P0.05). The improvement effect of TCM symptoms was better than that of the control group, especially in the patients with weak waist and knee, tinnitus and deafness, residual urine loss or incontinence, limb numbness, loss of judgment, decreased recognition, decreased computational power, personality disorder and more obvious tongue pulse (P0.01). P05), the scores of HDS,FAQ and MMSE were improved after the treatment of MMSE,HDS and FAQ, after the test of neuropsychological and cognitive ability, the scores of HDS,FAQ and MMSE were improved after treatment. But the effect of the treatment group was more obvious (P0.01) and the MMSE score of the treatment group was significantly higher than that of the control group (P0.05). In the control group, there was no significant difference before and after treatment, so Dihuang Yinao capsule had a good effect of promoting blood circulation and removing blood stasis. The therapeutic effect of Dihuang Yinao capsule on vascular dementia is not related to the age of the patients. It is widely used in the aged patients between 51 and 82 years of age. The curative effect is related to the stages of cerebrovascular disease, and the effect is better for the early stage of cerebrovascular disease dementia. The acute toxicity and long-term toxicity of the drug were observed and no side effects were found. Conclusion: Dihuang Yinao capsule is effective in the treatment of vascular dementia with kidney deficiency and blood stasis.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.13

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