中枢神经系统ERK信号通路在药物成瘾中的作用机制研究进展

发布时间：2019-01-08 13:58

【摘要】：药物成瘾是一种慢性复发性脑病。反复的药物暴露可引起脑环路产生神经适应性变化,导致强迫性觅药行为以及复吸。有许多研究发现,生物体内细胞间的信号转导级联放大通路介导的中枢神经系统奖赏环路的重塑,以及成瘾相关的学习和记忆的神经可塑性改变是药物成瘾的重要分子机制。研究表明细胞外调节激酶(extracellular signal-regulatedkinase,ERK)与药物成瘾引起的神经适应性、奖赏效应和觅药行为的复吸直接相关。因此,该文就ERK在药物成瘾中的作用机制做系统的综述。药物成瘾中ERK信号通路作用机制的研究将为深入理解药物成瘾的分子调控机制提供重要的理论基础,并为临床药物成瘾和复吸的治疗提供新的分子靶标和新的策略。
[Abstract]:Drug addiction is a chronic recurrent encephalopathy. Repeated drug exposure can lead to neuroadaptive changes in the brain loop, compulsive drug seeking behavior and relapse. Many studies have found that the remodeling of the reward loop in the central nervous system mediated by the signal transduction cascade amplification pathway in vivo and the neural plasticity of learning and memory associated with addiction are important molecular mechanisms of drug addiction. Studies have shown that extracellular regulated kinase (extracellular signal-regulatedkinase,ERK) is directly related to neuroadaptation, reward effect and drug seeking behavior induced by drug addiction. Therefore, the mechanism of ERK in drug addiction is reviewed systematically. The study on the mechanism of ERK signaling pathway in drug addiction will provide an important theoretical basis for further understanding the molecular regulatory mechanism of drug addiction and provide new molecular targets and strategies for the treatment of drug addiction and relapse.
【作者单位】：宁波大学医学院;宁波市微循环与莨菪类药研究所宁波大学行为神经科学研究中心;
【基金】：浙江省自然科学基金面上项目资助项目(No LY14H310002) 宁波市科技计划项目(No 2013C50033,2015C110026) 国家重点基础研究发展计划资助项目(No 2015CB553504)
【分类号】：R749.61

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