ApoEε4等位基因对MCI患者的认知功能及1H-MRS代谢物的影响
发布时间：2019-01-15 06:45
【摘要】：【目的】载脂蛋白E(apolipoprotein E,ApoE) ε4等位基因是阿尔茨海默病(Alzheimer disease,AD)的风险因素我们目的在于研究ε4等位基因对轻度认知功能障碍(mild cognitive impairment,MCI)患者的认知功能及海马区磁共振波谱(Magnetic Resonance Spectroscopy,MRS)代谢物变化的影响 【方法】对23例符合轻度认知功能障碍标准的患者进行简易精神状态检查法(mini mental state examination,MMSE)蒙特利尔认知评估(Montreal cognitiveassessment,MoCA)检查,通过PCR-RELP技术进行ApoE基因型鉴定,并进行双侧海马区域的MRS检查 【结果】(1) ApoEε4阳性的MCI患者MoCA总分及延迟记忆分数较阴性的MCI患者降低;(2) ApoEε4阳性的MCI患者两侧海马N-乙酰天门冬氨酸/肌酸(N.acetylaspartate/creatine,NAA/Cr)显著低于ε4阴性的MCI患者,而ε4阳性的MCI患者双侧海马胆碱/肌酸(choline/creatine,Cho/Cr)以及肌醇/肌酸(myo-inositol/creatine,MI/Cr)无明显不同;(3) MCI患者两侧海马NAA/Cr比率与延迟回忆的分数正相关 【结论】ApoEε4等位基因阳性MCI患者记忆损害更严重,并且海马区MRS代谢物的变化能够被MRS检测到
[Abstract]:[objective] the apolipoprotein E (apolipoprotein EpoE) 蔚 4 allele is a risk factor for Alzheimer's disease (Alzheimer disease,AD). Our aim is to study the effect of 蔚 4 allele on (mild cognitive impairment, with mild cognitive impairment. Effect of cognitive function and changes of magnetic resonance spectrum (Magnetic Resonance Spectroscopy,MRS) metabolites in hippocampus in patients with MCI [methods] 23 patients with mild cognitive impairment were examined by (mini mental state examination, with simple mental state test. MMSE) Montreal Cognitive Assessment (Montreal cognitiveassessment,MoCA) and ApoE genotypes were identified by PCR-RELP technique. MRS examination of bilateral hippocampal region [results] (1) the total MoCA score and delayed memory score in MCI patients with ApoE 蔚 4 positive were lower than those in MCI patients with negative ApoE 蔚 4; (2) the level of N acetylaspartate / creatine NAA / Cr in bilateral hippocampus of MCI patients with positive ApoE 蔚 4 was significantly lower than that of MCI patients with 蔚 4 negative, while choline/creatine, / creatine (choline/creatine,) in bilateral hippocampus of MCI patients with 蔚 4 positive was significantly lower than that of MCI patients with 蔚 4 positive. Cho/Cr and inositol / creatine (myo-inositol/creatine,MI/Cr) were not significantly different. (3) there was a positive correlation between bilateral hippocampal NAA/Cr ratio and delayed recall score in MCI patients [conclusion] ApoE 蔚 4 allele positive MCI patients had more severe memory impairment, and the changes of MRS metabolites in hippocampus could be detected by MRS.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.1
本文编号：2408939
[Abstract]:[objective] the apolipoprotein E (apolipoprotein EpoE) 蔚 4 allele is a risk factor for Alzheimer's disease (Alzheimer disease,AD). Our aim is to study the effect of 蔚 4 allele on (mild cognitive impairment, with mild cognitive impairment. Effect of cognitive function and changes of magnetic resonance spectrum (Magnetic Resonance Spectroscopy,MRS) metabolites in hippocampus in patients with MCI [methods] 23 patients with mild cognitive impairment were examined by (mini mental state examination, with simple mental state test. MMSE) Montreal Cognitive Assessment (Montreal cognitiveassessment,MoCA) and ApoE genotypes were identified by PCR-RELP technique. MRS examination of bilateral hippocampal region [results] (1) the total MoCA score and delayed memory score in MCI patients with ApoE 蔚 4 positive were lower than those in MCI patients with negative ApoE 蔚 4; (2) the level of N acetylaspartate / creatine NAA / Cr in bilateral hippocampus of MCI patients with positive ApoE 蔚 4 was significantly lower than that of MCI patients with 蔚 4 negative, while choline/creatine, / creatine (choline/creatine,) in bilateral hippocampus of MCI patients with 蔚 4 positive was significantly lower than that of MCI patients with 蔚 4 positive. Cho/Cr and inositol / creatine (myo-inositol/creatine,MI/Cr) were not significantly different. (3) there was a positive correlation between bilateral hippocampal NAA/Cr ratio and delayed recall score in MCI patients [conclusion] ApoE 蔚 4 allele positive MCI patients had more severe memory impairment, and the changes of MRS metabolites in hippocampus could be detected by MRS.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.1
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