帕罗西汀对急性脑梗死后抑郁患者抑郁状态及神经功能恢复的影响

发布时间：2019-01-16 00:26

【摘要】：目的:探讨帕罗西汀对急性脑梗死后抑郁患者抑郁状态及神经功能恢复的影响。方法:回顾性分析我院108例急性脑梗死后抑郁患者资料,按照用药不同分为观察组(54例)和对照组(54例)。两组患者均给予脱水、活血化瘀、抗凝、降纤等常规治疗。在此基础上,观察组患者给予盐酸帕罗西汀片20 mg,每天1次;对照组患者给予盐酸舍曲林片50 mg,每天1次。两组疗程均为4周。观察两组患者抑郁缓解情况和神经功能恢复情况,比较治疗前后汉密尔顿抑郁量表(HAMD)和改良的爱丁堡-斯堪的纳维亚卒中量表(MESSS)评分及不良反应发生情况。结果:观察组患者抑郁缓解总有效率(70.37%)和神经功能恢复总有效率(66.67%)均显著高于对照组(分别为38.89%、40.74%),差异均有统计学意义(P0.05)。治疗前,两组患者HAMD和MESSS评分比较,差异均无统计学意义(P0.05);治疗后,两组患者HAMD和MESSS评分均显著低于同组治疗前,且观察组显著低于同期对照组,差异均有统计学意义(P0.05)。治疗期间两组患者均未见明显不良反应发生。结论:帕罗西汀治疗急性脑梗死后抑郁疗效较好,可以有效缓解患者的抑郁症状,间接促进其神经功能的恢复,对急性脑梗死患者预后有积极作用,安全性亦较好。
[Abstract]:Objective: to investigate the effect of paroxetine on depression and recovery of nerve function in patients with depression after acute cerebral infarction. Methods: the data of 108 patients with depression after acute cerebral infarction in our hospital were retrospectively analyzed and divided into observation group (54 cases) and control group (54 cases). Both groups were given routine treatment such as dehydration, promoting blood circulation and removing blood stasis, anticoagulation, defibrillation and so on. On this basis, the patients in the observation group were given paroxetine hydrochloride once a day for 20 mg, and the patients in the control group were given sertraline hydrochloride tablets once a day for 50 mg,. The course of treatment was 4 weeks in both groups. Depression relief and neurological function recovery were observed in two groups. (HAMD) and (MESSS) scores of modified Edinburgh-Scandinavia Stroke scale and adverse reactions were compared before and after treatment. Results: the total effective rate of depression relief (70.37%) and the total effective rate of nerve function recovery (66.67%) in the observation group were significantly higher than those in the control group (38.89%, 40.74%, respectively), and the difference was statistically significant (P0.05). Before treatment, there was no significant difference in HAMD and MESSS scores between the two groups (P0.05). After treatment, the HAMD and MESSS scores of the two groups were significantly lower than those of the same group before treatment, and the observation group was significantly lower than the control group, the difference was statistically significant (P0.05). No significant adverse reactions occurred in both groups during treatment. Conclusion: paroxetine is effective in the treatment of depression after acute cerebral infarction, which can effectively relieve the depression symptoms, indirectly promote the recovery of neurological function, and has a positive effect on the prognosis and safety of patients with acute cerebral infarction.
【作者单位】：运城市中心医院药学部;运城市中心医院神经内科;
【分类号】：R743.33;R749.4

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