强迫症患者自知力水平与启动反应抑制功能关系的ERP研究

发布时间：2019-01-20 13:51

【摘要】：目的:探索强迫症患者自知力与反应抑制功能的关系。方法:记录42名强迫症患者(包括8名自知力不良的强迫症患者)和42名健康对照者在执行停止信号任务时诱发的ERPs。结果:与健康对照者相比,自知力不良和自知力良好组强迫症患者的抑制过程的反应时(Stop-signal reaction time,SSRT)更长(P0.05),但是强迫症两个组别之间没有显著性差异。两组强迫症患者在抑制成功试次中的Stop-N2波幅值均显著大于健康对照者(P0.05),两个强迫症组别之间无显著性差异。在抑制失败试次中,自知力良好的强迫症组的Stop-N2波幅值显著大于健康对照组(P0.05)。结论:自知力不良的强迫症患者可能并不存在更严重的启动抑制功能的下降,强迫症的启动反应抑制功能下降可能独立于自知力水平。
[Abstract]:Objective: to explore the relationship between cognitive ability and response inhibition in patients with obsessive-compulsive disorder (OCD). Methods: 42 patients with obsessive-compulsive disorder (including 8 patients with obsessive-compulsive disorder) and 42 healthy controls were recorded to induce ERPs. during the stop signal task. Results: the response time (Stop-signal reaction time,SSRT) of obsessive-compulsive disorder (OCD) patients with poor insight and good insight was longer than that of healthy controls (P0.05), but there was no significant difference between the two groups. The amplitude of Stop-N2 in OCD group was significantly higher than that in control group (P0.05), and there was no significant difference between the two groups. The amplitude of Stop-N2 in the OCD group with good insight was significantly higher than that in the healthy control group (P0.05). Conclusion: there may not be a more serious decrease in the initiation inhibition function of OCD patients with poor insight, and the decline of OCD priming response inhibition function may be independent of the level of insight.
【作者单位】：湖南农业大学教育学院;中南大学湘雅二医院医学心理中心;中南大学医学心理学研究所;
【基金】：湖南农业大学人才引进科学基金项目(项目号:15YJ06) 湖南省自然科学基金青年基金项目(项目号:2016JJ3067)
【分类号】：R749.7

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