精神分裂症患者血清胰岛素样生长因子-2水平的表达及临床意义

发布时间：2019-01-20 16:31

【摘要】：目的探讨精神分裂症患者血清胰岛素样生长因子(IGF)-2表达水平的变化及其临床意义。方法濮阳市精神卫生中心收治的精神分裂症患者62例为研究组,选择同期在该院进行健康体检的志愿者60名为对照组,采用阳性与阴性症状量表(PANSS)对患者精神状态进行评估,采用连线测试(TMT)A、数字符号编码测验(DSCT)、持续操作测验(CPT)和Stroop色词测验(SCWT)对两组认知功能状态进行评估,采用酶联免疫吸附法测定两组血清IGF-2水平,并对血清IGF-2与PANSS评分、TMTA、DSCT、CPT及SCWT相关性进行分析。结果研究组PANSS总分为(81.2±7.28)分、阳性症状分为(23.2±2.43)分、阴性症状分为(13.7±2.47)分、一般精神病理分(43.6±3.61)分。两组认知功能评估结果显示,与对照组相比,研究组TMTA时间较高,而DSCT得分、CPT分值较低(均P0.001);且SCWT 3项指标单词总数、颜色总数以及色/词总数均较低(P0.001)。研究组血清IGF-2浓度明显低于对照组(P0.001)。研究组中,首发患者与复发患者的血清IGF-2水平差异无统计学意义(P0.05)。相关性分析结果显示,研究组血清IGF-2水平与PANSS阴性症状分呈负相关(r=-0.348,P0.05),与CPT分值和SCWT 3项指标单词总数、颜色总数及色(词)总数均呈正相关关系(r=0.357,0.276,0.331,0.394;均P0.05)。结论精神分裂症患者血清IGF-2水平降低与患者认知损害程度及阴性症状有关,IGF-2可作为评估精神分裂症严重程度的一个生物学指标。
[Abstract]:Objective to investigate the expression of insulin-like growth factor (IGF)-2 in patients with schizophrenia and its clinical significance. Methods Sixty-two schizophrenic patients treated in Puyang Mental Health Center were selected as study group and 60 volunteers who underwent physical examination in the same period as control group. The positive and negative symptom scale (PANSS) was used to evaluate the mental state of the patients, and (TMT) A, digital symbol coding test (DSCT),) was used to test the mental state of the patients. Continuous operation test (CPT) and Stroop color word test (SCWT) were used to evaluate the cognitive function of the two groups. The levels of serum IGF-2 were measured by enzyme-linked immunosorbent assay (Elisa), and the serum IGF-2 and PANSS scores, TMTA,DSCT, were evaluated by enzyme-linked immunosorbent assay (Elisa). The correlation between CPT and SCWT was analyzed. Results the total score of PANSS, positive symptom, negative symptom and general psychopathology in the study group were (81.2 卤7.28), (23.2 卤2.43), (13.7 卤2.47) and (43.6 卤3.61), respectively. The results of cognitive function evaluation showed that compared with the control group, the study group had higher TMTA time, lower DSCT score and lower CPT score, and the total number of words, total color and color / word count of SCWT were lower than those of the control group (P0. 001). The serum IGF-2 concentration in the study group was significantly lower than that in the control group (P0. 001). In the study group, there was no significant difference in serum IGF-2 levels between the first and recurrent patients (P0.05). The results of correlation analysis showed that the serum IGF-2 level in the study group was negatively correlated with the score of negative symptoms of PANSS (r = 0.348, P 0.05), and with the scores of CPT and the total number of words in SCWT. The total number of colors and the total number of colors (words) were positively correlated (r = 0.3570.276 / 0.331/ 0.394); P 0.05). Conclusion the decrease of serum IGF-2 level in schizophrenic patients is related to the degree of cognitive impairment and negative symptoms. IGF-2 can be used as a biological index to evaluate the severity of schizophrenia.
【作者单位】：濮阳市精神卫生中心;
【分类号】：R749.3

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