基于体素的轻度阿尔茨海默病脑血流灌注及脑灰质结构特征

发布时间：2019-01-23 07:17

【摘要】：目的阿尔茨海默病(AD)早期诊断缺乏客观的影像学指标,本研究利用磁共振三维动脉自旋标记(3D ASL)技术和薄层三维T1加权结构成像,采用基于体素的分析方法(VBM),研究轻度AD脑血流灌注及脑灰质萎缩特征,并进行对比。资料与方法选择16例轻度AD患者(轻度AD组)和16例年龄匹配的认知功能正常者(对照组),分别进行磁共振3D ASL序列及3D T1薄层扰相梯度回波序列扫描,采用VBM对脑血流图及T1WI脑结构像进行全脑分析,比较两组患者的脑血流量(CBF)及灰质体积变化情况,并对CBF值和灰质体积进行相关分析。结果与对照组比较,轻度AD组血流灌注减低区主要在双侧楔前叶、楔叶、颞中回、颞上回、左侧海马旁回、左侧颞上极及右侧枕上回(t=3.84,P_(校正)0.05);轻度AD患者在双侧海马、杏仁核、颞上极、左侧海马旁回及左侧颞下回灰质体积较对照组存在萎缩(t=4.12,P_(校正)0.05);CBF与脑灰质萎缩在左侧海马旁回(r=0.50,P0.01)及左颞上极(r=0.42,P0.05)存在相关性。结论 VBM结合3D ASL技术能早期评价AD疾病进程中的脑萎缩和血流灌注变化,在部分重叠脑区的灌注减低区的CBF值与皮层体积减少具有相关性。
[Abstract]:Objective the early diagnosis of Alzheimer's disease (AD) lacks objective imaging indexes. In this study, 3D arterial spin labeling (3D ASL) and thin slice 3D T 1 weighted structure imaging were used to analyze Alzheimer's disease (AD). The voxel based analysis method (VBM), was used in this study. The characteristics of cerebral blood perfusion and gray matter atrophy in mild AD were studied and compared. Materials and methods Sixteen patients with mild AD (mild AD group) and 16 age-matched patients with normal cognitive function (control group) were examined with 3D ASL sequence and 3D T1-TLC scrambling gradient echo sequence, respectively. The cerebral blood flow volume (CBF) and gray matter volume were compared between the two groups by VBM, and the correlation between CBF value and gray matter volume was analyzed. Results compared with the control group, the decrease of blood perfusion in mild AD group was mainly located in bilateral precuneiform lobe, cuneiform lobe, middle temporal gyrus, superior temporal gyrus, left pariprahippocampal gyrus, left superior temporal pole and right superior occipital gyrus (t0. 84). The gray matter volume of bilateral hippocampus, amygdaloid nucleus, superior temporal pole, left parahippocampal gyrus and left inferior temporal gyrus were atrophied in patients with mild AD compared with those in control group. There was a correlation between CBF and gray matter atrophy in the left para-hippocampal gyrus (r = 0.50, P0.01) and the left superior temporal pole (r, 0.42, P 0.05). Conclusion VBM combined with 3D ASL can early evaluate the changes of cerebral atrophy and blood flow perfusion in the course of AD disease. The CBF value of the hypoperfusion area in some overlapped brain regions is correlated with the cortical volume reduction.
【作者单位】：北京大学第三医院放射科;北京大学第三医院康复科;北京大学第三医院神经内科;
【分类号】：R749.16

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