微卫星D6S274基因多态性与精神分裂症临床特征的关联研究

发布时间：2019-02-12 11:41

【摘要】：目的: 探讨江西汉族人群微卫星D6S274基因多态性与精神分裂症认知功能、阳性和阴性症状的关系。方法: 研究组174例住院患者（男100例，女74例），汉族，年龄18～40岁，符合国际疾病分类第10版（ICD-10）精神分裂症的诊断标准，3个月内未应用促智剂或未做电休克治疗(ECT)，病情基本控制，能配合完成认知功能测验；同期选取与之性别、年龄、种族和文化程度均衡可比的174例健康体检者为正常对照组(男98例，女76例)。所有入选研究对象对本研究知情同意。采用蒙特利尔量表（MoCA）对所有入选研究对象进行认知功能评定，采用阳性与阴性症状量表(PANSS)对患者精神症状进行评定。所有数据使用SPSS16.0软件进行t检验、单因素方差分析、组间两两比较、多元逐步线性回归、直线相关等统计分析。检验水准=0.05。结果: 1.研究组和对照组的MoCA总分、看图命名、视空间及执行功能、记忆及延迟记忆、语言、注意及抽象思维等得分比较，差异均有统计学意义(P＜0.05)；研究组中男女患者的看图命名和注意得分比较，差异有统计学意义(P＜0.05)， MoCA总分、视空间及执行功能、记忆及延迟记忆、语言、抽象思维和定向得分比较，差异无统计学意义（P＞0.05）。 2.研究组中不同基因型组间，MoCA量表的各级测试得分及PANSS量表的阴性症状分、PANSS总分比较，差异均有统计学意义(P＜0.05)；组间两两比较， D6S274的172bp患者的视空间/执行功能、看图命名、记忆及延迟记忆、注意、语言、抽象思维及定向得分低于其它基因型(P＜0.05)，PANSS量表阴性症状分和总分高于其它各基因型（P＜0.05）。 3.多元线性回归结果显示，D6S274的172bp与患者的视空间/执行功能、看图命名、记忆及延迟记忆、注意和语言方面以及PANSS总分、阴性症状分有关。 4.直线相关分析显示，精神分裂症患者的认知功能损害与阴性症状相关。结论 1.精神分裂症患者存在广泛的认知功能损害，主要表现在视空间/执行功能、看图命名、记忆及延迟记忆、注意、语言及抽象思维方面，且无性别差异。 2. D6S274多态性可能与精神分裂症认知功能的视空间/执行功能、看图命名、记忆及延迟记忆、注意和语言损害有关。 3. D6S274多态性可能影响精神分裂症的阴性症状，但与阳性症状可能无关。 4.精神分裂症认知功能损害与阴性症状呈负相关。
[Abstract]:Objective: to investigate the relationship between polymorphism of microsatellite D6S274 gene and cognitive function, positive and negative symptoms in Jiangxi Han population. Methods: the study group consisted of 174 inpatients (100 males and 74 females), the Han nationality, aged 1840 years, who were in accordance with the criteria for the diagnosis of schizophrenia in the 10th edition of the International Classification of Diseases (ICD-10). Within 3 months, patients with (ECT), were not treated with intelligence enhancer or electroshock therapy, and they were able to complete cognitive function test. At the same time, 174 healthy controls (male 98, female 76) were selected as the control group, with a balance of sex, age, race and education. All the selected subjects had informed consent to the study. All subjects were assessed with Montreal scale (MoCA) and positive and negative symptom scale (PANSS). All data were analyzed with SPSS16.0 software for t test, single factor analysis of variance, comparison between groups, multivariate stepwise linear regression, linear correlation and so on. Test level = 0.05. Results: 1. The scores of MoCA, visual space and executive function, memory and delayed memory, language, attention and abstract thinking were significantly different between the study group and the control group (P < 0. 05). In the study group, there was a significant difference in the scores of the nomenclature and attention (P < 0. 05), MoCA), the scores of visual space and executive function, memory and delayed memory, language, abstract thinking and orientation. The difference was not statistically significant (P > 0.05). 2. In the study group, there were significant differences in the scores of all levels of MoCA scale, the negative symptom score of PANSS scale and the total score of PANSS among different genotypic groups (P < 0. 05). The scores of visual space / executive function, image naming, memory and delayed memory, attention, language, abstract thinking and orientation in 172bp patients with D6S274 were lower than those of other genotypes (P < 0. 05). The negative symptom score and total score of PANSS scale were higher than those of other genotypes (P < 0. 05). 3. Multiple linear regression analysis showed that 172bp of D6S274 was related to visual space / executive function, image naming, memory and delayed memory, attention to language, total score of PANSS, negative symptom score. 4. Linear correlation analysis showed that cognitive impairment was associated with negative symptoms in schizophrenic patients. Conclusion 1. There were extensive cognitive impairment in schizophrenic patients, mainly in visual space / executive function, picture naming, memory and delayed memory, attention, language and abstract thinking, and there was no gender difference. 2. D6S274 polymorphism may be associated with visual space / executive function of cognitive function, picture naming, memory and delayed memory, attention and language impairment in schizophrenia. 3. D6S274 polymorphism may affect the negative symptoms of schizophrenia, but may not be associated with positive symptoms. 4. There was a negative correlation between cognitive impairment and negative symptoms in schizophrenia.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.3

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