伴自杀意念抑郁症患者静息态下比率低频振幅特征研究

发布时间：2019-02-13 05:36

【摘要】：目的探讨伴自杀意念抑郁症患者的脑活动特征及其与抑郁严重程度、自杀意念和自杀危险的关系。方法运用比率低频振幅方法对30例伴自杀意念、22例不伴自杀意念抑郁症患者和21名正常对照的静息态功能磁共振图像进行比较,采用汉密尔顿抑郁量表17项(Hamilton depression scale 17-item,HAMD-17)评估抑郁症患者的抑郁严重程度,Beck自杀意念量表评估抑郁症患者的自杀意念和自杀危险,并分析伴自杀意念抑郁症组与不伴自杀意念抑郁症组差异脑区的比率低频振幅值与抑郁症严重程度、自杀意念和自杀危险的关系。结果伴自杀意念抑郁症组左侧枕上回/枕中回、右侧枕中回/枕下回fALFF值高于对照组(P0.05,AlphaSim校正),不伴自杀意念抑郁症组左侧枕中回fALFF值高于对照组(P0.05,AlphaSim校正),伴自杀意念抑郁症患者左侧枕中回、右侧枕中回fALFF值高于不伴自杀意念组(P0.05,AlphaSim校正)。伴自杀意念组左侧枕中回(r=0.366,P=0.046)、右侧枕中回(r=0.513,P=0.004)fALFF值分别与HAMD-17总分呈正相关,与Beck自杀意念量表相关无统计学意义(P0.05)。结论伴自杀意念抑郁症患者的双侧枕中回脑功能存在异常,但本研究未发现这种异常脑功能活动与Beck自杀意念量表的自杀意念和自杀危险因子具有相关性。
[Abstract]:Objective to investigate the characteristics of brain activity in patients with suicidal ideation depression and its relationship with the severity of depression, suicide ideation and suicide risk. Methods the resting functional magnetic resonance images of 30 patients with suicidal ideation, 22 patients with depression without suicide ideation and 21 normal controls were compared with the ratio low frequency amplitude method. 17 items of Hamilton Depression scale (Hamilton depression scale) were used. (HAMD-17) to assess the severity of depression in patients with depression, and the Beck suicidal ideation scale to assess suicide ideation and suicide risk in patients with depression. The relationship between the ratio of low frequency amplitude of brain region and the severity of depression, suicide ideation and suicide risk was analyzed. Results the fALFF values of left superior occipital gyrus / middle occipital gyrus and right middle occipital gyrus / suboccipital gyrus in patients with depression with suicide ideation were higher than those in control group (P 0.05). The fALFF value of left occipital gyrus in depression group without suicidal ideation was higher than that in control group (P 0.05). The fALFF values of left middle occipital gyrus and right occipital middle gyrus in patients with depression with suicidal ideation were higher than those without suicide ideation (P0.05 AlphaSim correction). The fALFF values of left occipital middle gyrus and right occipital middle gyrus were positively correlated with the total score of HAMD-17 in the group with suicide ideation (r = 0.366), respectively (P 0.05). There was no significant correlation between the fALFF value and the Beck scale of suicidal ideation (P0.05). Conclusion the bilateral middle occipital gyrus function is abnormal in patients with suicidal ideation depression, but this study has not found that this abnormal brain function activity is correlated with the suicidal ideation and suicide risk factors of Beck suicide ideation scale.
【作者单位】：重庆医科大学附属第一医院精神科;西南大学心理学部;
【基金】：国家自然科学基金面上项目(编号:81571343) 重庆市科委应用开发一般项目(编号:cstc2014yykfA110030)
【分类号】：R749.4

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