脑脊液中花生四烯酸乙醇胺浓度变化与精神分裂症的病理机制

发布时间：2019-02-17 14:09

【摘要】：目的:探讨脑脊液中花生四烯酸乙醇胺(arachidonylethanolamide,anandamide,AEA)浓度与精神分裂症患者服药前后的变化及病理机制。方法:采集43例精神分裂症患者服药前后脑脊液样本,高效液相色谱法进行分析测定治疗前后样品中AEA含量,同时用阳性与阴性症状量表(positive and negative symptoms scale,PANSS)评定患者精神症状;并将测定结果和20名正常对照组CSF中AEA含量进行比较。结果:治疗前精神分裂症患者组CSF中AEA含量明显高于对照组(P0.01)。经药物治疗后患者CSF中AEA浓度显著下降(P0.01),并与对照组比较无显著性差异(P0.05)。结论:精神分裂症患者症状活跃期CSF的AEA含量增高,治疗后AEA含量降低,这一变化可能与精神病的病理机制有关,探索大麻系统(endocannabinoid system,ECS)与精神分裂症之间的关系对临床具有一定意义。
[Abstract]:Objective: to investigate the changes and pathological mechanism of ethanolamine arachidonate (arachidonylethanolamide,anandamide,AEA) in cerebrospinal fluid (CSF) and schizophrenia before and after administration. Methods: cerebrospinal fluid (CSF) samples were collected from 43 schizophrenic patients before and after taking medicine. The content of AEA in the samples before and after treatment was analyzed by HPLC. (positive and negative symptoms scale, was used to measure the positive and negative symptoms at the same time. (PANSS); The content of AEA in CSF was compared with that in 20 normal controls. Results: the content of AEA in CSF of schizophrenic patients before treatment was significantly higher than that in control group (P0.01). After drug treatment, the concentration of AEA in CSF decreased significantly (P0.01), and there was no significant difference compared with the control group (P0.05). Conclusion: the AEA content of CSF in active stage of schizophrenia is increased, but the content of AEA is decreased after treatment. This change may be related to the pathological mechanism of psychosis. Explore the (endocannabinoid system, of hemp system. The relationship between ECS and schizophrenia is of significance to clinical practice.
【作者单位】：重庆三峡医药高等专科学校;重庆三峡中心医院;重庆医科大学;
【基金】：重庆市教委科学技术研究项目(编号:KJ111802) 重庆市卫生局医学科研项目(编号:2012-1-096)
【分类号】：R749.3

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