早期血管性痴呆患者的效应连接研究

发布时间：2019-02-23 17:24

【摘要】：为探索早期血管性痴呆(VaD)患者与正常老年人脑区间效应连接(effective connectivity)的差异性,基于多导联脑电信号的相位信息,利用有向相位延迟指数(dPLI)算法,对两组受试者在执行oddball视觉探测任务过程中的脑电信号进行研究。结果表明:在θ频段,与正常老年人相比,早期VaD患者顶区到额区和顶区到中央区的连接强度均显著降低;正常老年人存在顶区脑活动相位超前、额区及中央区脑活动相位相对滞后的现象,而这种相位关系在早期VaD患者中被打破。因此,能够推测出远距离脑区间功能连接强度的下降,顶区核心地位的削弱,顶区相位超前、额区及中央区相位滞后现象的缺失可能是造成早期VaD患者认知功能下降的原因。该研究为VaD患者的发病机理研究、早期临床诊断研究提供了参考和依据。
[Abstract]:In order to explore the difference of interbrain interval effect (effective connectivity) between patients with early vascular dementia (VaD) and normal elderly, based on the phase information of multilead EEG, the directed phase delay index (dPLI) algorithm was used. The electroencephalogram (EEG) of two groups of subjects during the oddball visual detection task was studied. The results showed that in theta band, the connection strength between the parietal region and the frontal region and the parietal region to the central region in the early VaD patients was significantly lower than that in the normal elderly. The normal elderly have the phenomenon that the phase of brain activity in the parietal region is advanced and the phase of brain activity in the frontal and central regions is relatively lagging. This phase relationship was broken in the early VaD patients. Therefore, it can be inferred that the decline in the intensity of the functional connections in the long distance brain regions, the weakening of the core position of the parietal region, the phase advance in the parietal region and the absence of phase lag in the frontal and central regions may be the reasons for the decline of cognitive function in early VaD patients. This study provides a reference and basis for the study of pathogenesis and early clinical diagnosis of VaD patients.
【作者单位】：西安交通大学生物医学信息工程教育部重点实验室;西安交通大学第一附属医院神经内科;
【基金】：国家自然科学基金资助项目(31271061) 陕西省自然科学基础研究计划资助项目(2015JM6289) 中央高校基本科研业务费专项资金资助项目(xjj2014134)
【分类号】：R749.13

【相似文献】