重复经颅磁刺激联合改良电休克治疗对抑郁症状的疗效及对记忆功能的影响

发布时间：2019-02-23 19:27

【摘要】：目的探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)联合改良型无抽搐电休克治疗(modified electroconvulsive therapy,MECT)及单纯MECT治疗对抑郁症患者的疗效及其对记忆功能的影响。方法将120例抑郁症患者按随机、双盲的原则分成联合治疗组(实施rTMS联合MECT治疗)和单纯MECT治疗组(实施MECT治疗和rTMS伪刺激),每组60例。疗效评定采用汉密尔顿抑郁量表(HAMD),记忆功能评定采用修订韦氏记忆测验(WMS-RC)、行为记忆测验第2版(RBMTⅡ),3个量表分别于第1次MECT治疗开始前及第24次rTMS或伪刺激结束后的治疗终点进行评定。结果两组治疗终点的HAMD评分较治疗前均明显下降(P0.05),联合治疗组治疗终点评分较单纯MECT治疗组明显降低(P0.05);两组治疗终点WMS-RC评分中积累、背数、图片、再认、理解和联想评分均较治疗前明显降低(P0.05),联合治疗组治疗终点评分高于单纯MECT治疗组(P0.05);两组治疗终点RBMTⅡ评分中回忆姓名、回忆被藏物品、图片再认、故事即刻回忆、故事延迟回忆、脸部再认、路线即刻回忆、路线延迟回忆、信件即刻回忆、信件延迟回忆评分均较治疗前明显降低(P0.05),联合治疗组治疗终点评分高于单纯治疗组(P0.05)。结论 rTMS联合MECT治疗与单纯MECT治疗疗效相当,但对抑郁症患者记忆功能影响比单纯MECT治疗小。
[Abstract]:Objective to investigate the effect of repeated transcranial magnetic stimulation (repetitive transcranial magnetic stimulation,rTMS) combined with modified non-convulsive electroconvulsive therapy (modified electroconvulsive therapy,MECT) and MECT alone on depression and its effect on memory function. Methods one hundred and twenty patients with depression were randomly divided into two groups: the combined treatment group (rTMS combined with MECT) and the simple MECT group (MECT treatment and rTMS pseudo-stimulation). There were 60 cases in each group. The therapeutic effect was evaluated by Hamilton Depression scale (HAMD),) and modified Wechsler memory Test (WMS-RC) and Behavioral memory Test (RBMT 鈪，

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