伏隔核缺失后海洛因成瘾者线索诱导渴求的fMRI研究

发布时间：2019-02-28 19:28

【摘要】：目的 伏隔核是人类奖赏系统的重要结构，它参与人类的自然奖赏行为和药物奖赏行为，研究表明，伏隔核还可能参与了奖赏行为中的渴求处理过程，本研究通过观察分析探讨了伏隔核缺失的海洛因成瘾者，在完成药物线索诱导的渴求任务时大脑的反应及其与主观渴求程度之间变化的关系，探讨伏隔核缺失对人类渴求处理过程的影响，研究伏隔核缺失的海洛因成瘾者在完成药物线索诱导渴求任务时大脑反应及其与主观渴求程度变化的关系。 方法 10例伏隔核缺失的男性海洛因成瘾者(平均年龄33.8±6.6岁，受教育程度12±3年，，日吸毒量0.4~1g)和10例人口学及吸毒史相匹配的海洛因成瘾者(平均年龄30.7±5.5岁，受教育程度10.5±2.7年，日吸毒量0.4~1g)纳入该实验。研究对象接受图片药物线索诱导渴求的fMRI扫描。采集到的数据由SPM5软件进行分析。在完成图片药物线索诱导渴求任务的前后对被试者进行海洛因渴求程度评分，以获得被试者主观渴求的变化。 结果 1)暴露于图片药物线索之前，海洛因成瘾组平均渴求为（3.10±2.51），暴露于图片药物线索之后，海洛因成瘾组平均渴求为（4.40±3.36）。前后比较有明显的统计学差异（t4.713p0.019）。 2)呈现的药物相关图片成功激发了成瘾者的渴求，其被药物线索激活的脑区包括海马、尾状核，额下回、颞中回、颞下回、枕中回、顶下小叶（p0.001Voxel≥5）。 3)伏隔核缺失组暴露于药物图片线索前后其渴求均为0，无统计学差异（p0.05）。 4)被药物线索激活的脑区包括海马，颞中回、颞下回、顶下小叶、枕中回（p0.001Voxel≥5）。 5)伏隔核缺失组与海洛因成瘾组暴露于图片药物线索下俩组相比伏隔核活动减弱，楔前叶和舌回活动增强。 结论 伏隔核在海洛因成瘾者大脑对药物线索诱导渴求的过程中可能起重要作用。
[Abstract]:Objective Nucleus accumbens is an important structure of human reward system, which is involved in human natural reward behavior and drug reward behavior. Studies have shown that nucleus accumbens may also be involved in the craving process of reward behavior. In this study, we investigated the relationship between brain response and subjective craving degree in heroin addicts with nucleus accumbens deletion during drug-induced craving tasks. To investigate the effect of nucleus accumbens deletion on craving process in human, and to study the relationship between brain response and subjective craving degree in heroin addicts with nucleus accumbens deletion during drug cue-induced craving task. Methods Ten male heroin addicts with nucleus accumbens absence (mean age 33.8 卤6.6 years, education level 12 卤3 years) were enrolled in this study. 10 heroin addicts (mean age 30.7 卤5.5 years, education level 10.5 卤2.7 years, daily dose of drug use 0.4 g) matched with demography and history of drug use were included in the experiment. Subjects received fMRI scans for craving induced by pictorial drug cues. The collected data were analyzed by SPM5 software. Before and after completing the drug cue-induced craving task, the subjects were assessed with heroin craving degree to obtain the change of subjective craving. Results 1) before exposure to picture drug clues, the average craving was (3.10 卤2.51) in heroin addiction group, and (4.40 卤3.36) in heroin addiction group after exposure to picture drug clue. There was a significant statistical difference (t4.713p0.019) between before and after. 2) the drug-related images successfully stimulated the craving of drug addicts. The brain areas activated by drug clues included hippocampus, caudate nucleus, inferior frontal gyrus, middle temporal gyrus, inferior temporal gyrus, middle occipital gyrus and inferior parietal lobule (p0.001Voxel 鈮

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