情绪对脑功能连接的影响

发布时间：2019-03-12 17:48

【摘要】：目前许多研究报道了神经精神障碍疾病患者静息态脑功能连接(rsFC)的异常变化,但对脑功能连接受情绪的影响还不甚了解。本研究用高兴和悲伤两类电影片段分别诱导20位健康受试产生相应的情绪,同时采集功能磁共振图像(fMRI)。以前扣带回(ACC)、背外侧前额叶(DLPFC)和杏仁核为种子点,利用低频涨落的相关性分析了执行功能、注意力以及情感神经网络系统功能连接受情绪的影响,并对个人情感强度特质作回归来考察个体差异。我们发现与高兴的情绪相比,在悲伤状态下,大脑左侧的背外侧前额叶与后扣带回之间存在显著的正向功能连接,且连接程度与个体情感唤醒度成正比。表明人们在悲伤时会加强对负性情绪和信息的处理,且情绪化较强的人,脑内功能连接更加不稳定。
[Abstract]:At present, many studies have reported the abnormal changes of resting brain functional connections (rsFC) in patients with neuropsychiatric disorders, but the effect of emotion on brain functional connections is not well understood. In this study, 20 healthy subjects were induced to produce corresponding emotions with happy and sad movie fragments respectively. Meanwhile, (fMRI). Images were collected from functional magnetic resonance imaging (fMRI) at the same time. The (DLPFC) and amygdala of the dorsolateral prefrontal lobe of the anterior cingulate gyrus (ACC),) were used as seed points. The effects of emotion on executive function, attention and functional connection of emotional neural network system were analyzed by using the correlation of low frequency fluctuations. And to make the regression to the individual emotion intensity trait to examine the individual difference. We found that there was a significant positive functional connection between the dorsolateral prefrontal lobe and the posterior cingulate gyrus in the left side of the brain in the sad state compared with the happy mood, and the degree of connection was proportional to the degree of emotional awakening. It shows that people can strengthen the processing of negative emotions and information when they are sad, and the functional connections in the brain are more unstable in the people with strong emotion.
【作者单位】：清华大学医学院生物医学影像研究中心;
【基金】：数据分析受认知神经科学与学习国家重点实验室开放课题基金支持(实验数据在NIMHP50MH60451支持下采集)
【分类号】：R749

【共引文献】