抑郁症患者血清微量元素、铜蓝蛋白与执行功能的关系

发布时间：2019-03-13 12:23

【摘要】：目的:探讨抑郁症患者(MDD)血清微量元素、铜蓝蛋白(Cp)与执行功能的关系.方法:采用威斯康星卡片分类测验(WCST)及连线测验(TMT)评估35例符合美国精神障碍统计与诊断手册第5版(DSM-5)诊断标准的抑郁症患者和30例正常对照者的执行功能,检测两组的血清铜(Cu)、锌(Zn)和Cp含量并探讨这3种物质与执行功能的相关性.结果:抑郁组患者在TMT(反应时)和WCST测验(分类数、总错误数、持续错误数和非持续错误数)的成绩均低于对照组,差异具有统计学意义(P0.05);抑郁组患者血清Zn、Cp水平明显低于对照组,Cu离子含量显著高于正常对照组,差异具有统计学意义(P0.05);抑郁组患者血清中的Cp含量与TMT(反应时、错误数)的成绩呈正相关,与WCST非持续性错误数呈负相关;抑郁组Cu含量与TMT(提笔数)呈正相关.结论:抑郁症患者的执行功能可能与铜和铜蓝蛋白密切相关.
[Abstract]:Objective: to investigate the relationship between serum trace elements, ceruloplasmin (Cp) and executive function in patients with depression (MDD). Methods: the executive function of 35 patients with depression and 30 normal controls were assessed by Wisconsin Card sorting Test (WCST) and Wired Test (TMT), which met the diagnostic criteria of American Handbook of Statistics and diagnosis of Mental Disorder (DSM-5). The levels of serum copper, (Cu), zinc, (Zn) and Cp in the two groups were measured and the correlation between the three substances and executive function was investigated. Results: the scores of TMT (reaction time) and WCST (classification, total errors, persistent errors and non-persistent errors) in depression group were significantly lower than those in control group (P0.05). The level of serum Zn,Cp in depression group was significantly lower than that in control group, and the content of Cu ion in depression group was significantly higher than that in normal control group (P0.05). The levels of Cp in serum of depression group were positively correlated with the scores of TMT (reaction time, error number), and negatively correlated with the number of non-persistent errors of WCST, and the content of Cu in depression group was positively correlated with TMT (number of pens). Conclusion: the executive function of depression patients may be closely related to copper and ceruloplasmin.
【作者单位】：暨南大学管理学院;广州市妇女儿童医疗中心;江门市中心医院心理门诊;暨南大学附属第一医院精神医学科;广州军区广州总医院药剂科;
【基金】：国家自然科学基金项目(81671351) 广东省省级科技计划项目(2014A020212401) 广州市科技计划项目(201509010012)
【分类号】：R749.4

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