氯胺酮在抑郁症患者无抽搐电休克治疗中的疗效分析

发布时间：2019-03-14 19:02

【摘要】：目的观察氯胺酮在抑郁症患者无抽搐电休克治疗(MECT)中的疗效。方法选择拟行无抽搐电休克治疗的抑郁症患者60例,年龄18~60岁,随机分为氯胺酮组和丙泊酚组,每组30例。在MECT前静注阿托品0.5~1.0mg、丙泊酚1.0mg/kg(丙泊酚组)或氯胺酮0.8mg/kg(氯胺酮组),待患者睫毛反射消失后静注琥珀胆碱0.7~1.0mg/kg。分别在第2、4、6次治疗后完成汉密尔顿抑郁量表(HAMD)。记录患者每次治疗时抽搐时间、抽搐指数、能量百分比、呼吸恢复时间及不良反应情况。结果随着治疗次数增加两组HAMD总分均明显下降(P0.05)。氯胺酮组HAMD总分下降明显快于丙泊酚组(P0.05)。两组患者抽搐时间、抽搐指数、能量百分比、呼吸恢复时间差异均无统计学意义。结论在抑郁症患者MECT治疗中氯胺酮降低HAMD评分的效果优于丙泊酚。
[Abstract]:Objective to observe the efficacy of ketamine in the treatment of (MECT) without convulsive shock. Methods Sixty patients with depression, aged 18 to 60 years, were randomly divided into ketamine group and propofol group (n = 30, each group) without electroconvulsive therapy. The patients were divided into two groups: ketamine group (n = 30) and propofol group (n = 30). Before MECT, atropine 0.5 / 1.0 mg, propofol 1.0mg/kg (propofol group) or ketamine 0.8mg/kg (ketamine group) were injected intravenously. After the eyelash reflex disappeared, intravenous injection of succincholine 0.7 / 1.0 mg / kg 路kg ~ (- 1) was given to the patients by intravenous injection of Atropine, propofol 1.0mg/kg (propofol group) or ketamine 0.8mg/kg (ketamine group). The Hamilton Depression scale (HAMD).) was completed after 2,4 and 6 treatments, respectively. The convulsive time, convulsive index, energy percentage, respiratory recovery time and adverse reaction were recorded at each treatment. Results with the increase of treatment times, the total score of HAMD in both groups decreased significantly (P0.05). The total score of HAMD in ketamine group was significantly lower than that in propofol group (P0.05). There was no significant difference in convulsive time, convulsive index, energy percentage and respiratory recovery time between the two groups. Conclusion ketamine is better than propofol in reducing HAMD score in depression patients with MECT.
【作者单位】：南京脑科医院麻醉科;南京市妇幼保健院麻醉科;南京脑科医院精神科;南京中医药大学第二附属医院麻醉科;
【分类号】：R749.4

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