阿兹海默症中S-亚硝基化蛋白质组确定及功能分析
发布时间：2019-03-14 21:03
【摘要】：正蛋白质的S-亚硝基化修饰在阿兹海默症(AD)发病机制中的影响已有初步研究成果,实验证明阿兹海默症中错误折叠的蛋白质形成与聚集均与蛋白质亚硝基化修饰有关联。近期,来自巴基斯坦卡拉奇大学和德国哥廷根大学医学中心的研究团队对阿兹海默症中发生S-亚硝基化修饰的蛋白质进行了筛查,并确定出45个蛋白靶点,其中超氧岐化酶(SOD2)[Mn]、果糖
[Abstract]:The effect of S-nitroso modification of normal protein on the pathogenesis of Alzheimer's disease (AD) has been preliminarily studied. It has been proved that the formation and aggregation of misfolded proteins in Alzheimer's disease are related to the modification of protein nitrosation. Recently, a team from the University of Karachi in Pakistan and the University of Gottingen Medical Center in Germany screened proteins modified with S-nitroso in Alzheimer's disease and identified 45 protein targets. Among them, superoxide dismutase (SOD2) [Mn], fructose
【分类号】：R749.16
本文编号：2440371
[Abstract]:The effect of S-nitroso modification of normal protein on the pathogenesis of Alzheimer's disease (AD) has been preliminarily studied. It has been proved that the formation and aggregation of misfolded proteins in Alzheimer's disease are related to the modification of protein nitrosation. Recently, a team from the University of Karachi in Pakistan and the University of Gottingen Medical Center in Germany screened proteins modified with S-nitroso in Alzheimer's disease and identified 45 protein targets. Among them, superoxide dismutase (SOD2) [Mn], fructose
【分类号】：R749.16
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