急性PTSD脑血流灌注的磁共振研究
发布时间：2019-03-15 15:38
【摘要】：目的 本项实验研究创伤后三个月急性PTSD患者，通过静息态磁共振动脉自旋标记成像技术，探讨创伤后急性PTSD患者局部脑血流灌注的变化,以及局部脑血流灌注与其临床症状之间的关系。 方法 采用非侵入性脉冲式动脉自旋标记（PASL）技术与SPM5方法研究矿难发生3个月时受试者局部脑血流灌注(rCBF)变化。研究对象包括30名未经药物治疗的急性PTSD患者，其中男17人，，女13人，所有患者符合DSM-Ⅳ的诊断标准，临床医师诊断量表（CAPS）用来评估PTSD的症状程度：CAPS(29.6±18.8）；并用汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)对PTSD的相关症状焦虑和抑郁状况进行评估：HAMA（10.5±7.7）、HAMD（9.2±5.9）。36名健康对照者，其中男21人，女15人。最后采用Xjview提取异常脑区作为感兴趣区（ROI），对感兴趣区灌注值与PTSD患者CAPS、HAMA及HAMD积分分别进行相关性分析。 结果 与健康对照组相比，急性PTSD患者右侧颞叶、左侧颞中回、右侧额中回、右侧内侧眶回、右侧岛叶、右侧枕中回和右侧楔前叶脑血流灌注明显降低（p㩳0.05）；在感兴趣区研究中发现，右侧岛叶灌注值与CAPS（r=-0.396,p=0.030）及HAMA积分（r=-0.465,p=0.010）呈负相关。 结论 本研究结果显示急性创伤后应激障碍患者局部脑血流灌注明显降低；且患者症状的严重程度和焦虑情绪分别与右侧岛叶灌注相关，提示局部脑血流灌注值（rCBF）可以预测PTSD临床症状的严重程度。
[Abstract]:Objective to study the changes of regional cerebral blood flow in patients with acute PTSD three months after trauma by using resting magnetic resonance angiography (SMI) to investigate the changes of regional cerebral blood flow in patients with acute PTSD after trauma. And the relationship between regional cerebral blood perfusion and its clinical symptoms. Methods non-invasive pulsed arterial spin-labeled (PASL) and SPM5 methods were used to study the changes of regional cerebral blood flow perfusion (rCBF) in the subjects 3 months after the mine accident. The subjects included 30 untreated patients with acute PTSD, including 17 males and 13 females, all of whom met the diagnostic criteria of DSM- 鈪
本文编号：2440759
[Abstract]:Objective to study the changes of regional cerebral blood flow in patients with acute PTSD three months after trauma by using resting magnetic resonance angiography (SMI) to investigate the changes of regional cerebral blood flow in patients with acute PTSD after trauma. And the relationship between regional cerebral blood perfusion and its clinical symptoms. Methods non-invasive pulsed arterial spin-labeled (PASL) and SPM5 methods were used to study the changes of regional cerebral blood flow perfusion (rCBF) in the subjects 3 months after the mine accident. The subjects included 30 untreated patients with acute PTSD, including 17 males and 13 females, all of whom met the diagnostic criteria of DSM- 鈪
本文编号：2440759
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