尿液中AD7c-NTP水平诊断阿尔茨海默病准确性的系统评价
发布时间：2019-03-17 07:52
【摘要】：目的评价尿液中阿尔茨海默相关神经丝蛋白(Alzheimer-associated neuronal thread protein, AD7c-NTP)水平诊断阿尔茨海默病(Alzheimer's disease, AD)的价值,以期为临床决策提供依据。 方法计算机检索Medline、EMbase、Cochrane图书馆、中国生物医学文献数据库、中国知网、万方和维普等数据库,所有检索均截止至2013年3月,收集关于尿液中AD7c-NTP与AD临床诊断标准比较诊断阿尔茨海默病价值的诊断性试验,对纳入研究进行资料提取并应用QUADAS条目进行方法学质量评估后,使用Stata/SE12.0软件进行Meta分析,采用双变量混合效应模型计算合并灵敏度和特异度、合并似然比和诊断优势比,评价和探索异质性、发表偏倚,并绘制汇总受试者工作特征曲线(Summary receiver operating characteristic curve, SROC curve)和计算曲线下面积(area under the SROC curve, AUC),以评价尿AD7c-NTP诊断AD的价值。 结果共纳入9篇文献,其中经临床诊断标准确认的很可能／可能AD患者841例,非AD患者992例。异质性检验结果显示各纳入研究结果间存在统计学异质性,采用双变量混合效应模型进行Meta分析,结果显示尿液中AD7c-NTP诊断很可能/可能AD的合并灵敏度为0.87(95%CI,0.80-0.91),特异度为0.89(95%CI,0.87-0.91),阳性似然比8.13(95%CI,6.60-10.02),阴性似然比0.15(95%CI,0.10-0.22),SROC曲线下面积(AUC)为0.90(0.87-0.93)。对于很可能AD的病例,合并灵敏度为0.89(95%CI,0.86-0.92),合并特异度为0.90(95%CI,0.88-0.92),合并PLR和NLR分别为8.88(95%CI,7.09-11.12)和0.12(95%CI,0.09-0.16),SROC曲线下面积(AUC)为0.95(95%CI,0.92-0.96)。 结论尿液中AD7c-NTP是一种比较好的诊断很可能AD的无创性检查方法,有较高的灵敏度和特异度,但AD7c-NTP能否作为一种早期的生物标志物仍需进一步研究。
[Abstract]:Objective to evaluate the value of urinary Alzheimer's associated neurofilament (Alzheimer-associated neuronal thread protein, AD7c-NTP) levels in the diagnosis of Alzheimer's disease (Alzheimer's disease, AD) in order to provide evidence for clinical decision-making. Methods the Medline,EMbase,Cochrane Library, Chinese Biomedical Literature Database, China knowledge Network, Wanfang and Vip databases were searched by computer, all of which were up to March 2013. A diagnostic test was collected to compare the clinical diagnostic criteria of AD7c-NTP and AD in urine for the diagnosis of Alzheimer's disease, and after data extraction from the inclusion study and methodological quality assessment using the QUADAS entry, Stata/SE12.0 software was used for Meta analysis. The combined sensitivity and specificity, likelihood ratio and diagnostic advantage ratio were calculated by bivariate mixed effect model, and heterogeneity and publication bias were evaluated and explored. The receiver operating characteristic curve (Summary receiver operating characteristic curve, SROC curve) and the area under the curve (area under the SROC curve, AUC),) were drawn to evaluate the diagnostic value of urinary AD7c-NTP in the diagnosis of AD. Results A total of 9 articles were included, of which 841 patients with AD and 992 patients with non-AD were confirmed by clinical diagnostic criteria. The results of heterogeneity test showed that there was statistical heterogeneity among the study results. The bivariate mixed effect model was used for Meta analysis. The results showed that the combined sensitivity of AD7c-NTP diagnosis in urine was 0.87 (95% CI, 95% CI). 0.80 渭 0.91), specificity 0.89 (95% CI, 0.87 渭 0.91), positive likelihood ratio 8.13 (95% CI, 6.60 渭 10.02), negative likelihood ratio 0.15 (95% CI, 0.10 脳 0.22), positive likelihood ratio 8.13 (95% CI, 6.60 渭 10.02), negative likelihood ratio 0.15 (95% CI, 0.10 渭 0.22). The area under SROC curve was 0.90 (0.87 渭 0.93). For the most likely cases of AD, the combined sensitivity was 0.89 (95% CI, 0.86 渭 0.92), the combined specificity was 0.90 (95% CI, 0.88 渭 0.92), and the combined PLR and NLR were 8.88 (95% CI, 95% CI), respectively. The area (AUC) under curves 7.09 / 11.12) and 0.12 (95% CI, 0.09 / 0.16), SROC) was 0.95 (95% CI, 0.92 渭 0.96). Conclusion AD7c-NTP in urine is a good non-invasive method for the diagnosis of AD with high sensitivity and specificity, but whether AD7c-NTP can be used as an early biomarker should be further studied.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.16;R446.12
本文编号：2442082
[Abstract]:Objective to evaluate the value of urinary Alzheimer's associated neurofilament (Alzheimer-associated neuronal thread protein, AD7c-NTP) levels in the diagnosis of Alzheimer's disease (Alzheimer's disease, AD) in order to provide evidence for clinical decision-making. Methods the Medline,EMbase,Cochrane Library, Chinese Biomedical Literature Database, China knowledge Network, Wanfang and Vip databases were searched by computer, all of which were up to March 2013. A diagnostic test was collected to compare the clinical diagnostic criteria of AD7c-NTP and AD in urine for the diagnosis of Alzheimer's disease, and after data extraction from the inclusion study and methodological quality assessment using the QUADAS entry, Stata/SE12.0 software was used for Meta analysis. The combined sensitivity and specificity, likelihood ratio and diagnostic advantage ratio were calculated by bivariate mixed effect model, and heterogeneity and publication bias were evaluated and explored. The receiver operating characteristic curve (Summary receiver operating characteristic curve, SROC curve) and the area under the curve (area under the SROC curve, AUC),) were drawn to evaluate the diagnostic value of urinary AD7c-NTP in the diagnosis of AD. Results A total of 9 articles were included, of which 841 patients with AD and 992 patients with non-AD were confirmed by clinical diagnostic criteria. The results of heterogeneity test showed that there was statistical heterogeneity among the study results. The bivariate mixed effect model was used for Meta analysis. The results showed that the combined sensitivity of AD7c-NTP diagnosis in urine was 0.87 (95% CI, 95% CI). 0.80 渭 0.91), specificity 0.89 (95% CI, 0.87 渭 0.91), positive likelihood ratio 8.13 (95% CI, 6.60 渭 10.02), negative likelihood ratio 0.15 (95% CI, 0.10 脳 0.22), positive likelihood ratio 8.13 (95% CI, 6.60 渭 10.02), negative likelihood ratio 0.15 (95% CI, 0.10 渭 0.22). The area under SROC curve was 0.90 (0.87 渭 0.93). For the most likely cases of AD, the combined sensitivity was 0.89 (95% CI, 0.86 渭 0.92), the combined specificity was 0.90 (95% CI, 0.88 渭 0.92), and the combined PLR and NLR were 8.88 (95% CI, 95% CI), respectively. The area (AUC) under curves 7.09 / 11.12) and 0.12 (95% CI, 0.09 / 0.16), SROC) was 0.95 (95% CI, 0.92 渭 0.96). Conclusion AD7c-NTP in urine is a good non-invasive method for the diagnosis of AD with high sensitivity and specificity, but whether AD7c-NTP can be used as an early biomarker should be further studied.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.16;R446.12
【参考文献】
相关期刊论文 前3条
1 郝建华;李江;何亮;张然蓉;张健华;蔡安季;林毓岑;;阿尔茨海默病患者尿中AD7c-NTP检测的意义[J];中国热带医学;2011年08期
2 闫鹏;王蓉;杜怡峰;沈伦乾;;老年性痴呆患者尿中AD7c-NTP含量的研究[J];山东大学学报(医学版);2009年06期
3 田金洲;时晶;张学凯;倪敬年;张伯礼;王永炎;;2011年美国阿尔茨海默病最新诊断标准解读[J];中国医学前沿杂志(电子版);2011年04期
相关硕士学位论文 前1条
1 曾瀛;尿AD7c-NTP在阿尔茨海默病早期诊断中的价值[D];南昌大学;2011年
，本文编号：2442082
本文链接：https://www.wllwen.com/yixuelunwen/jsb/2442082.html
最近更新
教材专著
