多奈哌齐辅助治疗对轻-中度麻痹性痴呆病人的疗效

发布时间：2019-03-19 19:51

【摘要】：【目的】探讨多奈哌齐对轻-中度麻痹性痴呆病人认知的疗效。【方法】将临床确诊轻-中度麻痹性痴呆的病人47例根据用药情况分为观察组(n=24例)及对照组(n=23例),对照组按标准驱梅疗法予大剂量青霉素治疗14 d后继予苄星青霉素治疗3周,观察组在对照组的治疗基础上加用多奈哌齐5 mg每天一次治疗。评估基线期、治疗后4周、12周MMSE评分、CDR评分,血清及脑脊液TRUST滴度变化。【结果】青霉素治疗后,血液及脑脊液内TRUST滴度下降甚至转阴;基线期及治疗4周后两组MMSE、CDR评分无明显统计学差异,治疗12周时观察组各项评分均较对照组高(P0.05),且无明显不良反应。【结论】在有效驱梅的基础上,多奈哌齐可改善轻-中度麻痹性痴呆的认知功能、痴呆程度,且安全、耐受性良好,可能是麻痹性痴呆的辅助治疗手段之一。
[Abstract]:[objective] to investigate the effect of donepazide on cognition of patients with mild to moderate paralytic dementia. [methods] 47 patients with mild to moderate paralytic dementia were divided into observation group (n = 24) and control group (n = 23) according to the medication condition, and the patients with mild to moderate paralytic dementia were divided into observation group (n = 24) and control group (n = 23). The control group was treated with high-dose penicillin for 14 days and then treated with benzylpenicillin for 3 weeks according to the standard banmei therapy. The observation group was treated with 5 mg of Donepezil once a day on the basis of the treatment of the control group. The baseline period, 4 and 12 weeks after treatment, MMSE score, CDR score, serum and cerebrospinal fluid TRUST titers were evaluated. [results] after penicillin treatment, the TRUST titers in blood and cerebrospinal fluid decreased and even turned negative. There was no significant difference in MMSE,CDR scores between the two groups at baseline stage and 4 weeks after treatment. The scores of observation group were higher than those of control group at 12 weeks after treatment (P0.05), and there was no obvious adverse reaction. [conclusion] on the basis of effective treatment of plum, the scores of observation group were higher than those of control group (P0.05). Donepezil can improve the cognitive function, dementia degree, safety and tolerance of mild to moderate paralytic dementia, which may be one of the auxiliary therapy for paralytic dementia.
【作者单位】：中山大学孙逸仙纪念医院神经内科;
【基金】：广东省自然科学基金(2014A030313085)
【分类号】：R749.16

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