精神分裂症患者血清同型半胱氨酸与注意及执行功能的相关性
发布时间：2019-03-30 13:42
【摘要】：目的:探讨血清同型半胱氨酸(Homocysteine,Hcy)与精神分裂症注意及执行功能的相关性。方法:选取门诊及住院精神分裂症患者118人,在该院康复科社会志愿者中选取健康者72例为正常对照组。测定空腹静脉血清同型半胱氨酸(15μmol/L为高Hcy)、叶酸、维生素B12含量;采用连续操作测验(CPT)评定持续注意能力,威斯康星卡片分类测验(WCST)评定执行功能。结果:患者组血清Hcy值高于正常对照组[(21.8±7.7)μmol/L vs.(15.4±5.2)μmol/L,P0.05],男性患者血清Hcy值高于女性患者[(27.9±4.4)μmol/L vs.(16.5±3.5)μmol/L,P0.05]。患者组中高血清Hcy者共61人(51.69%),男性多于女性(61.6%vs.40.4%,P0.05)。患者组的CPT和WCST测验得分均低于正常对照组,高Hcy患者的CPT和WCST测验得分均低于正常Hcy患者(均P0.05)。患者组的血清Hcy值与CPT正确反应数及WCST正确测验数、分类完成数得分均呈负相关(r=-0.83、-0.78、-0.74,均P0.01),而与CPT干扰项错误数及WCST持续错误数、随机错误数得分呈正相关(r=0.65、0.84、0.78,均P0.01)。结论:本研究提示,精神分裂症患者的血清Hcy值异常升高与其注意及执行功能密切相关。
[Abstract]:Objective: to investigate the relationship between serum homocysteine (Homocysteine,Hcy) and attention and executive function in schizophrenia. Methods: 118 out-patient and inpatients with schizophrenia were selected and 72 healthy volunteers were selected as normal control group. Fasting venous serum homocysteine (15 渭 mol / L, high homocysteine), folic acid and vitamin B12 were measured, continuous operation test (CPT) was used to evaluate persistent attention, Wisconsin card sorting test (WCST) was used to evaluate executive function. Results: the serum Hcy level in the patient group was higher than that in the normal control group [(21.8 卤7. 7) 渭 mol/L vs. (15.4 卤5. 2) 渭 mol/L,P0.05]. The serum Hcy level in male patients was higher than that in female patients [(27.9 卤4.4) 渭 mol/L vs., (16.5 卤3.5) 渭 mol/L,P0.05]. There were 61 patients (51.69%) with high serum Hcy in the patient group, and the male was more than the female (61.6% vs. 40.4%, P0.05). The scores of CPT and WCST in the patients group were lower than those in the normal control group, and the scores of CPT and WCST in the patients with high Hcy were lower than those in the normal Hcy patients (P0.05). In the patient group, the serum Hcy value was negatively correlated with the correct response to CPT, the correct test number of WCST, and the score of classification completion (r = 0.83, 0.78, 0.74, both P0.01), while it was negatively correlated with the number of CPT interference item errors and the number of WCST persistent errors. The scores of random errors were positively correlated (r = 0.65, 0.84, 0.78, P 0.01). Conclusion: this study suggests that the abnormal increase of serum Hcy level in schizophrenic patients is closely related to their attention and executive function.
【作者单位】： 杭州市第七人民医院;浙江大学心理健康教育与咨询中心;
【分类号】：R749.3
[Abstract]:Objective: to investigate the relationship between serum homocysteine (Homocysteine,Hcy) and attention and executive function in schizophrenia. Methods: 118 out-patient and inpatients with schizophrenia were selected and 72 healthy volunteers were selected as normal control group. Fasting venous serum homocysteine (15 渭 mol / L, high homocysteine), folic acid and vitamin B12 were measured, continuous operation test (CPT) was used to evaluate persistent attention, Wisconsin card sorting test (WCST) was used to evaluate executive function. Results: the serum Hcy level in the patient group was higher than that in the normal control group [(21.8 卤7. 7) 渭 mol/L vs. (15.4 卤5. 2) 渭 mol/L,P0.05]. The serum Hcy level in male patients was higher than that in female patients [(27.9 卤4.4) 渭 mol/L vs., (16.5 卤3.5) 渭 mol/L,P0.05]. There were 61 patients (51.69%) with high serum Hcy in the patient group, and the male was more than the female (61.6% vs. 40.4%, P0.05). The scores of CPT and WCST in the patients group were lower than those in the normal control group, and the scores of CPT and WCST in the patients with high Hcy were lower than those in the normal Hcy patients (P0.05). In the patient group, the serum Hcy value was negatively correlated with the correct response to CPT, the correct test number of WCST, and the score of classification completion (r = 0.83, 0.78, 0.74, both P0.01), while it was negatively correlated with the number of CPT interference item errors and the number of WCST persistent errors. The scores of random errors were positively correlated (r = 0.65, 0.84, 0.78, P 0.01). Conclusion: this study suggests that the abnormal increase of serum Hcy level in schizophrenic patients is closely related to their attention and executive function.
【作者单位】： 杭州市第七人民医院;浙江大学心理健康教育与咨询中心;
【分类号】：R749.3
【参考文献】
相关期刊论文 前10条
1 田国强;甘建光;;连续操作测验检测持续性注意功能[J];中国临床神经科学;2009年06期
2 张文跃;祁小飞;;同型半胱氨酸代谢失衡与精神分裂症[J];精神医学杂志;2007年03期
3 朱春燕,汪凯,Lee TMC;执行功能与精神分裂症[J];心理科学进展;2004年05期
4 朱荣鑫,张志s，
本文编号：2450133
本文链接：https://www.wllwen.com/yixuelunwen/jsb/2450133.html
最近更新
教材专著
