高频经颅磁刺激治疗精神分裂症阴性症状的疗效评估

发布时间：2019-04-08 09:26

【摘要】：目的:研究分析重复经颅磁刺激(rTMS)治疗精神分裂症阴性症状的疗效评估。方法:随机选取本院精神科患有精神分裂症患者66例,且均残留明显的阴性症状。患者被随机分为两组,研究组使用高频rTMS刺激治疗,对照组使用rTMS刺激伪治疗,两组患者分别治疗为期1个月,并进行1个月随访,通过对PANSS、SANS、PRM指标分值测试,对患者临床症状进行分析对比。其中运用的工具为:用于测量PANSS阳性与阴性症状量表、成人安全筛查表检测患者是否可以进行高频rTMS刺激、测量SANS指标的阴性症状量表(SANS)以及对心理、认知功能进行测试的剑桥自动化成套神经心理测试等进行临床评估。对比分析两组患者治疗前后PANSS、SANS、PRM指标的总分评分并对比两组的疗效。结果:治疗期间,研究组患者1个月末:(1)SANS评分,即SAF、SVB、SISL、SVB、SPT、及SAD指标较基线期均有所下降,且SANS总分降低;(2)PANSS评分,即POS、NEG、GPS指标较基线期降低,且总分下降;(3)PRM评分,即N、T1、T2指标较基线期较低,差异有统计学意义(P0.05)。对照组患者SANS、PANSS及PRM评分较基线期不明显变化,差异无统计学意义(P0.05)。随访期间,研究组患者2个月末:SANS评分,即SAF、SVB、SISL、SVB、SPT、及SAD指标较1月末均有所下降,且SANS总分降低;(2)PANSS评分,即POS、NEG、GPS指标较1月末降低,且总分下降;(3)PRM评分,即N、T1、T2指标较1月末较低,差异有统计学意义(P0.05)。对照组对照组患者SANS、PANSS及PRM评分较1月末不明显变化,差异无统计学意义(P0.05)。结论:采用高频rTMS刺激治疗,精神分裂患者阴性症状可得到缓解,效果在治疗后2个月后较为明显,并且通过高频rTMS刺激,可提高患者的认知功能。
[Abstract]:Objective: to evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) in the treatment of negative symptoms of schizophrenia. Methods: 66 patients with schizophrenia in our psychiatric department were randomly selected, all of whom had significant negative symptoms. The patients were randomly divided into two groups: the study group was treated with high frequency rTMS stimulation, and the control group was treated with rTMS stimulation false therapy. The patients in the two groups were treated for a period of 1 month and followed up for 1 month. The clinical symptoms of the patients were analyzed and compared. The tools used are: the PANSS positive and negative symptom scale, the adult safety screening table to detect whether patients can be stimulated with high frequency rTMS, the negative symptom scale (SANS) of SANS index, and the psychological control. Cambridge automated neuropsychological tests for cognitive function testing were used for clinical evaluation. The total score of PANSS,SANS,PRM before and after treatment was compared between the two groups and the curative effect was compared between the two groups. Results: at the end of one month after treatment, the patients in the study group were: (1) the SANS score, that is, the indexes of SAF,SVB,SISL,SVB,SPT, and SAD were lower than those in the baseline stage, and the total score of SANS was lower; (2) PANSS score, that is, POS,NEG,GPS index was lower than baseline stage, and total score decreased; (3) PRM score, that is, N, T _ 1, T _ 2 index was lower than baseline stage, the difference was statistically significant (P0.05). There was no significant difference in SANS,PANSS and PRM scores between baseline stage and control group (P0.05). During the follow-up period, at the end of 2 months in the study group, the SANS score, that is, the indexes of SAF,SVB,SISL,SVB,SPT, and SAD were decreased, and the total score of SANS was lower than that at the end of January. (2) PANSS score, that is, POS,NEG,GPS index was lower than that at the end of January, and total score decreased; (3) PRM score, that is, N, T _ 1, T _ 2 index was lower than that at the end of January, the difference was statistically significant (P0.05). There was no significant difference in SANS,PANSS and PRM scores between control group and control group at the end of January (P0.05). Conclusion: the negative symptoms of patients with schizophrenia can be relieved by high-frequency rTMS stimulation, and the effect is more obvious 2 months after treatment. The cognitive function of patients can be improved by high-frequency rTMS stimulation.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R749.3

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