中国人群中单核苷酸多态性位点rs165599与脑区体积的相关性

发布时间：2019-04-11 21:08

【摘要】：目的探讨健康中国汉族人群精神分裂症易感基因儿茶酚-O-甲基转移酶(COMT)单核苷酸多态性位点rs165599与部分脑区体积的相关性。方法纳入299名健康中国汉族志愿者,对所有志愿者行MRI,采用VBM8软件测量19个脑区体积,以SnaP Shot法对rs165599位点进行基因分型,采用线性回归模型分析rs165599位点与所选19个脑区体积的相关性。结果总体样本和男性样本中rs165599位点与所选19个脑区体积均无相关性(P均0.05);女性样本中rs165599位点与岛叶及丘脑体积呈显著相关(P=0.04、0.01),效应等位基因(C)携带者岛叶体积大于非效应等位基因(T)携带者,丘脑体积小于非效应等位基因(T)携带者,经多重检验校正后rs165599与岛叶及丘脑体积无相关性(P=0.76、0.15)。结论女性中rs165599可能与岛叶及丘脑体积具有相关性。
[Abstract]:Aim to investigate the relationship between single nucleotide polymorphism (rs165599) of catechol-O-methyltransferase (COMT) single nucleotide polymorphism (SNPs) and brain volume in healthy Chinese Han population. Methods Ninety-nine healthy Chinese Han volunteers were enrolled in this study. The volumes of 19 brain regions were measured by VBM8 software with MRI,. The rs165599 loci were genotyped by SnaP Shot method. Linear regression model was used to analyze the correlation between rs165599 locus and the selected 19 brain area volumes. Results there was no correlation between the rs165599 locus and the volume of the 19 selected brain regions in the total and male samples (P 0.05). There was a significant correlation between rs165599 locus and the volume of island lobe and thalamus in female samples (P < 0. 04, 0. 01). The island leaf volume of effector allele (C) carrier was larger than that of non-effector allele (T) carrier (P < 0. 01). The volume of thalamus was smaller than that of non-effector allele (T) carriers, and there was no correlation between rs165599 and the volume of island lobe and thalamus (P < 0. 76, 0. 15). Conclusion rs165599 may be related to the volume of island lobe and thalamus in women.
【作者单位】：昆明医科大学第一附属医院医学影像科;昆明医科大学第一附属医院微创神经外科;
【分类号】：R445.2;R749.3

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