不同剂量多奈哌齐治疗血管性痴呆疗效的Meta分析

发布时间：2019-05-06 06:58

【摘要】：目的:本研究通过对不同剂量胆碱酯酶抑制剂多奈哌齐治疗血管性痴呆的随机对照试验进行Meta分析,评价多奈哌齐治疗血管性痴呆的有效性和安全性,为其临床应用提供有效的循症医学证据。方法:计算机检索中国学术期刊(CNKI)数据库、维普中文数据库、万方数据库、Pubmed、Cochrane Library、Embase等数据库中有关多奈哌齐治疗血管性痴呆的随机对照试验。依据纳入排除标准收集文献。对收集的669篇文章进行筛选,最终纳入8篇符合条件的文献,提取相关数据,采用Revman5.3软件进行统计分析,评价不同剂量多奈哌齐对血管性痴呆的疗效及安全性。结果:多奈哌齐5mg/d组与多奈哌齐10mg/d组均较对照组治疗血管性痴呆有明显疗效,可明显提高简易智力状态检查量表(MMSE)的分值,且无剂量相关性。统计学分析结果为多奈哌齐5mg/d组与对照组:I2=21%,WMD=0.74,95%CI(0.44,1.05);多奈哌齐10mg/d与对照组:I2=0%,WMD=1.10,95%CI(0.58,1.62);多奈哌齐10mg/d组与多奈哌齐5mg/d组:I2=0%,WMD=0.29,95%CI(-0.05,0.64)。结论:根据此系统评价结果,5mg、10mg多奈哌齐对血管性痴呆患者认知功能均有显著改善作用,疗效无明显剂量相关性。
[Abstract]:Objective: to evaluate the efficacy and safety of Donepezil in the treatment of vascular dementia by Meta analysis in a randomized controlled trial of different doses of Donepezil, a cholinesterase inhibitor, in the treatment of vascular dementia. To provide effective medical evidence for its clinical application. Methods: the randomized controlled trials of Donepezil in the treatment of vascular dementia were searched by computer in the databases of Chinese academic journal (CNKI), Wip Chinese database, Wanfang database, Pubmed,Cochrane Library,Embase and so on. Collect documents according to the exclusion criteria. Six hundred and sixty-nine articles were selected and 8 articles were selected. The data were extracted and analyzed statistically with Revman5.3 software to evaluate the efficacy and safety of different doses of Donepezil in the treatment of vascular dementia. Results: Donepezil 5mg/d group and Donipezil 10mg/d group were more effective in treating vascular dementia than those in control group. The scores of (MMSE) in mini mental state examination scale were significantly increased, and there was no dose correlation between the two groups. The results of statistical analysis showed that the 5mg/d group and the control group were I2, WMD, 0.74, 95% CI (0.44, 1.05), and the 10mg/d and the control group were I 2? 0%, WMD? 1.10, 95% CI (0.58, 1.62). 10mg/d group and 5mg/d group: I2%, WMD 0.29,95% CI (- 0.05,0.64). Conclusion: according to the results of this systematic evaluation, 5mg and 10mg Donepezil could significantly improve cognitive function in patients with vascular dementia, and there was no significant dose correlation between the therapeutic effect and the cognitive function of the patients with vascular dementia.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R749.13

【参考文献】