可乐定透皮贴治疗儿童抽动障碍疗效与安全性的系统评价和Meta分析
发布时间：2019-05-15 22:39
【摘要】：目的评价可乐定透皮贴治疗儿童抽动障碍(TD)的临床疗效与安全性。方法检索维普科技期刊数据库、万方数据库、中国知网、中国生物医学文献数据库、EMCC、Pub Med、OVID及Cochrance图书馆,搜集可乐定透皮贴治疗TD的RCT和NRCT,检索时间均为建库至2016年8月30日。由2名研究者独立筛选文献、提取资料并评价纳入文献的偏倚风险后,采用Rev Man5.3软件Meta分析。结果最终纳入6篇文献,5篇为RCT,1篇未描述具体随机方法。共纳入1 043例TD患儿,病例组632例,对照组411例。对照组为氟哌啶醇3篇、硫必利2篇和安慰剂2篇。13篇文献比较了可乐定透皮贴与氟哌啶醇治疗TD的疗效,文献间异质性小,固定效应模型分析,两组的耶鲁综合抽动严重程度量表(YGTSS)减分率差异有统计学意义(P0.001),MD=21.82(95%CI:20.97~22.88)。22篇文献比较了可乐定透皮贴与硫必利治疗TD的疗效,文献间异质性大,随机效应模型分析,两组YGTSS减分率差异无统计学意义(P=0.43),MD=10.66(95%CI:-15.67~36.99)。32篇文献以不同评估方式比较了可乐定透皮贴与安慰剂的疗效,不适宜合并分析,描述性分析显示可乐定透皮贴剂能够有效降低YGTSS的分数。46篇文献均报道了不良反应的发生情况,可乐定透皮贴主要的不良反应包括:局部皮肤瘙痒、发红(17例),口干(10例),头晕(8例),血压下降(4例)等。3篇文献比较了可乐定透皮贴与氟哌啶醇的不良反应发生率[3.7%(8/218)vs 17.8%(37/208)],差异有统计学意义(P0.001)。2篇文献比较了可乐定透皮贴与硫必利的不良反应发生率[15.8%(16/101)vs 31.0%(35/113)],差异有统计学意义(P=0.009)。2篇文献比较了可乐定透皮贴与安慰剂的不良反应发生率[6.2%(24/384)vs 9.3%(12/129)],差异无统计学意义(P=0.24)。结论现有证据表明,可乐定透皮贴与治疗TD的传统药物相比疗效相当,但其不良反应的发生率低,且使用方便。
[Abstract]:Objective to evaluate the clinical efficacy and safety of clonidine transdermal patch in the treatment of children with tic disorder (TD). Methods the database of Weipu sci-tech journals, Wanfang database, China knowledge network, Chinese biomedical literature database, EMCC,Pub Med,OVID and Cochrance library were searched. The RCT and NRCT, of clonidine transdermal paste in the treatment of TD were collected. The retrieval time is from the establishment of the database to August 30, 2016. After two researchers independently screened the literature, extracted the data and evaluated the bias risk of the literature, the Rev Man5.3 software Meta was used to analyze the literature. Results six literatures were included, 5 of which were RCT,1 articles without description of specific random methods. A total of 1043 children with TD were included, 632 cases in the case group and 411 cases in the control group. In the control group, there were 3 haloperidol, 2 thiopride and 2 placebo. Thirteen articles compared the efficacy of clonidine transdermal paste and haloperidol in the treatment of TD, the heterogeneity between the literature was small, and the fixed effect model was analyzed. There was significant difference in (YGTSS) score reduction rate between the two groups (P0.001), MD=21.82 (95%CI:20.97~22.88). 22 articles compared the efficacy of clonidine transdermal patch and thiopride in the treatment of TD. There was no significant difference in YGTSS score reduction rate between the two groups (P 鈮，
本文编号：2477816
[Abstract]:Objective to evaluate the clinical efficacy and safety of clonidine transdermal patch in the treatment of children with tic disorder (TD). Methods the database of Weipu sci-tech journals, Wanfang database, China knowledge network, Chinese biomedical literature database, EMCC,Pub Med,OVID and Cochrance library were searched. The RCT and NRCT, of clonidine transdermal paste in the treatment of TD were collected. The retrieval time is from the establishment of the database to August 30, 2016. After two researchers independently screened the literature, extracted the data and evaluated the bias risk of the literature, the Rev Man5.3 software Meta was used to analyze the literature. Results six literatures were included, 5 of which were RCT,1 articles without description of specific random methods. A total of 1043 children with TD were included, 632 cases in the case group and 411 cases in the control group. In the control group, there were 3 haloperidol, 2 thiopride and 2 placebo. Thirteen articles compared the efficacy of clonidine transdermal paste and haloperidol in the treatment of TD, the heterogeneity between the literature was small, and the fixed effect model was analyzed. There was significant difference in (YGTSS) score reduction rate between the two groups (P0.001), MD=21.82 (95%CI:20.97~22.88). 22 articles compared the efficacy of clonidine transdermal patch and thiopride in the treatment of TD. There was no significant difference in YGTSS score reduction rate between the two groups (P 鈮，
本文编号：2477816
本文链接：https://www.wllwen.com/yixuelunwen/jsb/2477816.html
最近更新
教材专著
