神经肽Y基因多态性和精神分裂症的关联研究

发布时间：2019-05-16 09:39

【摘要】：目的·探讨中国汉族人群神经肽Y(NPY)基因多态性与精神分裂症的相关性。方法·采用Taq Man探针基因分型技术对678例精神分裂症患者(病例组)及685例正常对照者(对照组)的NPY基因多态性(rs16148、rs1859290、rs16147、rs16478)进行分型。应用SHEsis在线软件比较各组间的等位基因频率、基因型频率、单倍型频率分布有无差异。结果·rs16478位点基因型频率分布在成年起病精神分裂症(AOS)组和对照组间存在边缘统计学差异(χ~2=6.66,P=0.036,P_(校正)=0.144)。在隐性模式下,rs1859290位点CC基因型的频率分布在男性病例组和对照组间差异有统计学意义(P=0.012,OR=0.97,95%CI为0.94~0.99,P_(校正)=0.048)。单倍型CCTA(由rs16148、rs1859290、rs16147、rs16478构成)的频率分布在男性AOS组和对照组间的差异有统计学意义(8.1%vs 13.2%,OR=0.57,P=0.010,P校正=0.040)。结论·在中国汉族人群中,NPY基因可能是精神分裂症的易感基因。
[Abstract]:Objective to investigate the relationship between neuropeptide Y (NPY) gene polymorphism and schizophrenia in Chinese Han population. Methods NPY gene polymorphism (rs16148,rs1859290,rs16147,rs16478) in 678 patients with schizophrenia (case group) and 685 normal controls (control group) were typed by Taq Man probe genotyping. SHEsis online software was used to compare whether there were differences in allele frequency, genotypic frequency and haplotype frequency distribution among the three groups. Results there was significant difference in genotypic frequency distribution of rs16478 locus between (AOS) group and control group (蠂 ~ 2 鈮，

本文编号：2478196