母亲孕期补充叶酸与其子女孤独症谱系障碍发病风险的Meta分析

发布时间：2019-05-25 02:13

【摘要】：目的定量综合分析母亲孕期补充叶酸与其子女孤独症谱系障碍(ASD)发病风险的相关性。方法计算机全面检索PubMed、Embase、Scopus、Corchrane Liabrary、EBSCO、中国知网、万方、维普及中国生物医学文献数据库等电子数据库,收集有关母亲孕期叶酸补充与儿童ASD发病风险的文献,以OR及其95%CI为合并效应量,运用Stata 12.0软件进行Meta分析,并进行发表偏倚评估和敏感性分析。结果根据纳入及排除标准共纳入10篇文献,包含15项研究,累计病例4 459例,对照1 225 835例。Meta分析结果显示,总体人群中母亲孕期补充叶酸可显著降低其子女ASD发病风险(OR=0.798,95%CI:0.669~0.952,P=0.012)。亚组分析结果显示,亚洲人群中母亲孕期补充叶酸可能与其子女ASD发病风险降低有关(OR=0.664,95%CI:0.428~1.032),但未达到统计学意义(P=0.069);西方人群中母亲孕期补充叶酸可降低其子女ASD发病风险(OR=0.817,95%CI:0.671~0.996,P=0.045)。结论母亲孕期补充叶酸可能可降低其子女ASD发病风险,在西方人群中效果较明显。
[Abstract]:Objective to quantitatively analyze the correlation between folic acid supplementation during pregnancy and the risk of (ASD) in children with autism spectrum disorder. Methods the electronic databases such as PubMed,Embase,Scopus,Corchrane Liabrary,EBSCO, China knowledge Network, Wanfang and Wei Popularization Chinese Biomedical Literature Database were searched by computer, and the literatures about maternal folic acid supplementation during pregnancy and the risk of ASD in children were collected. Using OR and its 95%CI as combined effects, Meta analysis was carried out with Stata 12.0 software, and published bias evaluation and sensitivity analysis were carried out. Results according to the criteria of inclusion and exclusion, a total of 10 literatures were included, including 15 studies, with a cumulative case of 4459 and a control of 1225835. Meta-analysis showed that, Folic acid supplementation during pregnancy significantly reduced the risk of ASD in children (OR=0.798,95%CI:0.669~0.952,P=0.012). Subgroup analysis showed that folic acid supplementation during pregnancy may be related to the reduced risk of ASD in children (OR=0.664,95%CI:0.428~1.032), but not statistically significant (P 鈮，

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