MRI乳头体体积测量及其在认知功能障碍性疾病的初步应用
发布时间：2019-05-27 14:28
【摘要】：目的； 观察和分析正常成人乳头体(MB)体积的对称性、随年龄演变趋势和性别差异,初步说明MB体积在正F常成年人群的分布情况。观察和分析以轻度认知功能障碍(MCI)和阿尔茨海默病(AD)为代表的认知功能障碍性疾病的MB体积变化,初步探讨认知功能障碍性疾病所致的MB体积变化趋势及其临床应用价值。 方法: 选择正常成人50例和年龄匹配的正常对照、MCI、AD患者各25例。采用GE HD-X3.0T超导型磁共振扫描仪采集正常成人和正常对照MR图像；下载ADNI的MCI、AD患者MR图像。使用ITK-SNAP Version2.0.0软件在三维高分辨率T1WI解剖像测量MB体积,对每个MB重复测量两遍,取平均值为测量体积,取同一研究对象双侧测量体积之和为测量总体积,并以全脑体积进行标准化处理得到标化体积和标化总体积。采用SPSS19.0统计软件包对MB标化体积指标进行统计分析：正常成人侧别、年龄段、性别分别进行配对样本,检验、单因素方差分析和独立样本t检验;MCI、AD组患者侧别、性别分别进行配对样本,检验、独立样本t检验;正常对照、MCI、AD组间进行单因素方差分析。 结果: 正常成人MB标化体积和标化总体积平均值为100.2±11.2mm3和200.4±20.1mm3,按照侧别、年龄段和性别分析MB标化体积指标均无统计学差异。MCI、AD组内侧别研究显示,MB标化体积右侧(MCI92.2±19.4mm3, AD79.1±14.5mm3)大于左侧(MCI82.9±17.2mm3, AD71.2±15.6mm3),差异均存在统计学意义(tmC1=3.920,tAD=3.422,p0.05)。MCI、AD组内性别比较显示,两性间MB标化体积指标无统计学差异。正常对照,MCI及AD组间MB标化体积、标化总体积单因素方差分析均存在统计学差异(F标化体积=35.965,F标化总体积=21.610,p0.05),并且正常对照(标化体积101.3±11.0mm3、标化总体积202.5±19.7mm3)MCI(标化体积87.6±18.8mm3、标化总体积175.2±34.7mm3)AD(标化体积75.2±15.4mm3、标化总体积1503±27.8mm3),差异均存在统计学意义(p0.05)；三组间右侧、左侧组MB标化体积单因素方差分析同样存在统计学差异(F右侧标化体积=14.782,F左侧标化体积=23.366,p0.05),并且正常对照(右侧102.5±10.4mm3、左侧100.0±11.7mm3)MCI(右侧92.2±19.41mm3、左侧82.9±17.2mm3)AD(右侧79.1±14.5mm3、左侧71.2±15.6mm3),差异均存在统计学意义(p0.05)。 结论： 1.正常成人MB的体积分布特点：双侧基本对称、无明显性别差异,坡重要的是随年龄增加萎缩不明显。 2.认知功能障碍性疾病,如MCI、AD可伴有MB体积萎缩;MB体积萎缩可于AD早期出现,且与病变进程相一致,可作为AD早期较为敏感的脑体积变化指标,但特异性差 3. MCI、AD患者左侧MB体积萎缩较右侧明显,提示在认知功能障碍性疾病中MB受损的非对称性
[Abstract]:the purpose of the invention; The symmetry of the volume of the normal adult papilla (MB) was observed and analyzed, and the distribution of the MB volume in the normal adult population was preliminarily explained with the trend of age and the sex difference. The changes of MB volume in cognitive dysfunction caused by mild cognitive impairment (MCI) and Alzheimer's disease (AD) were observed and analyzed, and the change of MB volume caused by cognitive dysfunction and its clinical application were discussed. Value. Methods: The normal control, MCI and AD of 50 normal adults and 50 normal adults were selected. The normal adult and normal control MR images were collected by the GE HD-X3.0T superconducting magnetic resonance scanner, and the MCI and AD of the ADNI were downloaded. The MR image of the person was measured. Using the ITK-SNAP Version2.0.0 software, the MB volume was measured on the three-dimensional high-resolution T1WI anatomical image, and the measurement was repeated twice for each MB. The average value was the measured volume, and the sum of the two-sided measurement volume of the same study object was taken as the measurement volume. the total volume is measured and the normalized treatment is performed with the total brain volume to obtain the labeled volume and The volume index of MB is analyzed by using the SPSS19.0 statistical software package: the paired samples, the test, the single-factor analysis of variance and the independent sample t test are performed for the normal adult side, age and sex, respectively; and the side and the sex of the patients in the MCI and AD groups are respectively matched. Sample, test, independent sample t-test; normal control, MCI, AD group variance of prime Analysis. Results: The average volume and standard volume of the normal adult MB were 100.2-11.2 mm3 and 200.4-20.1 mm3, and the MB-labeled volume was analyzed according to the lateral, age and gender There was no statistical difference in the index. The inside of the MCI and AD group showed that the right of the MB standard volume (MCI92.2, 19.4 mm3, AD79.1, 14.5 mm3) was greater than that of the left (MCI82.9, 17.2 mm3, AD71.2, 15.6 mm3), and there was a statistical difference (tmC1 = 3.920, tAD = 3.4 22, p0.05). There was no statistical difference in the product index. There was a statistical difference between the normal control, the MCI and the AD group, and the variance analysis of the total volume of the standardized total volume (F-labeled volume = 35.965, F-labeled total volume = 21.610, p0.05), and the normal control (labeled volume 101). The difference was statistically significant (p0, with a total volume of 87.6-188mm3, a total volume of 175.2-34.7 mm3) of MCI (a labeled volume of 87.6-188mm3, a total volume of 175.2-34.7 mm3) of AD (labeled volume of 75.2-15.4 mm3, and a labeled total volume of 1503-27.8 mm3). There was also a statistical difference between the three groups on the right side and on the left side group of MB standard volume single factor analysis of variance (F-side scale volume = 14.782, F left-side labeled volume = 23.366, p0.05), and the normal control (right 102.5-10.4 mm3, left 100.0-11.7 mm3) MCI (right 92.2-19.41 mm3, left-hand 82.9-17.2 mm3) AD (right 79). 1 to 14.5 mm3 (71.2 to 15.6 mm3 on the left), and there was a difference in the difference meaning ( p0.05). Conclusion:1. The volume distribution of normal adult MB: bilateral basic symmetry, no significant gender difference, slope weight It is not obvious to increase the atrophy with age.2. The cognitive dysfunction disease, such as MCI, AD, can be associated with the atrophy of MB, and the atrophy of MB can occur in the early stage of AD and in line with the pathological process, which can be used as the early AD of AD. sensitive brain volume The change index, but the specific difference 3. MCI, the left-hand MB volume of the AD patient is obviously lower than the right side, and the prompt is to be recognized.
【学位授予单位】：天津医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.16
本文编号：2486223
[Abstract]:the purpose of the invention; The symmetry of the volume of the normal adult papilla (MB) was observed and analyzed, and the distribution of the MB volume in the normal adult population was preliminarily explained with the trend of age and the sex difference. The changes of MB volume in cognitive dysfunction caused by mild cognitive impairment (MCI) and Alzheimer's disease (AD) were observed and analyzed, and the change of MB volume caused by cognitive dysfunction and its clinical application were discussed. Value. Methods: The normal control, MCI and AD of 50 normal adults and 50 normal adults were selected. The normal adult and normal control MR images were collected by the GE HD-X3.0T superconducting magnetic resonance scanner, and the MCI and AD of the ADNI were downloaded. The MR image of the person was measured. Using the ITK-SNAP Version2.0.0 software, the MB volume was measured on the three-dimensional high-resolution T1WI anatomical image, and the measurement was repeated twice for each MB. The average value was the measured volume, and the sum of the two-sided measurement volume of the same study object was taken as the measurement volume. the total volume is measured and the normalized treatment is performed with the total brain volume to obtain the labeled volume and The volume index of MB is analyzed by using the SPSS19.0 statistical software package: the paired samples, the test, the single-factor analysis of variance and the independent sample t test are performed for the normal adult side, age and sex, respectively; and the side and the sex of the patients in the MCI and AD groups are respectively matched. Sample, test, independent sample t-test; normal control, MCI, AD group variance of prime Analysis. Results: The average volume and standard volume of the normal adult MB were 100.2-11.2 mm3 and 200.4-20.1 mm3, and the MB-labeled volume was analyzed according to the lateral, age and gender There was no statistical difference in the index. The inside of the MCI and AD group showed that the right of the MB standard volume (MCI92.2, 19.4 mm3, AD79.1, 14.5 mm3) was greater than that of the left (MCI82.9, 17.2 mm3, AD71.2, 15.6 mm3), and there was a statistical difference (tmC1 = 3.920, tAD = 3.4 22, p0.05). There was no statistical difference in the product index. There was a statistical difference between the normal control, the MCI and the AD group, and the variance analysis of the total volume of the standardized total volume (F-labeled volume = 35.965, F-labeled total volume = 21.610, p0.05), and the normal control (labeled volume 101). The difference was statistically significant (p0, with a total volume of 87.6-188mm3, a total volume of 175.2-34.7 mm3) of MCI (a labeled volume of 87.6-188mm3, a total volume of 175.2-34.7 mm3) of AD (labeled volume of 75.2-15.4 mm3, and a labeled total volume of 1503-27.8 mm3). There was also a statistical difference between the three groups on the right side and on the left side group of MB standard volume single factor analysis of variance (F-side scale volume = 14.782, F left-side labeled volume = 23.366, p0.05), and the normal control (right 102.5-10.4 mm3, left 100.0-11.7 mm3) MCI (right 92.2-19.41 mm3, left-hand 82.9-17.2 mm3) AD (right 79). 1 to 14.5 mm3 (71.2 to 15.6 mm3 on the left), and there was a difference in the difference meaning ( p0.05). Conclusion:1. The volume distribution of normal adult MB: bilateral basic symmetry, no significant gender difference, slope weight It is not obvious to increase the atrophy with age.2. The cognitive dysfunction disease, such as MCI, AD, can be associated with the atrophy of MB, and the atrophy of MB can occur in the early stage of AD and in line with the pathological process, which can be used as the early AD of AD. sensitive brain volume The change index, but the specific difference 3. MCI, the left-hand MB volume of the AD patient is obviously lower than the right side, and the prompt is to be recognized.
【学位授予单位】：天津医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.16
【引证文献】
相关期刊论文 前1条
1 骈文婷;张敬;杨明铭;;Alzheimer病乳头体MRI体积测量研究[J];中国中西医结合影像学杂志;2013年04期
，本文编号：2486223
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