2002年、2006年及2012年河北省住院精神分裂症患者氯氮平使用变化趋势调查

发布时间：2019-06-02 23:21

【摘要】：目的调查2002年、2006年及2012年河北省精神分裂症患者住院期间氯氮平使用变化趋势。方法以2002年、2006年及2012年在河北省各级精神卫生机构中住院的精神分裂症患者为研究对象,其中2002年543例,2006年608例,2012年2 911例。采用自编精神药物使用调查表分别对3年间患者氯氮平使用情况进行调查。比较不同住院次数及不同级别医院3年间单一氯氮平使用频率、合并其他药物氯氮平使用频率(合并氯氮平使用频率)及氯氮平使用总频率。结果 2002年、2006年及2012年住院精神分裂症患者单一氯氮平使用频率、合并氯氮平使用频率及氯氮平使用总频率均呈下降趋势(P0.05)。首次住院患者单一氯氮平使用频率及氯氮平使用总频率均呈下降趋势(P0.05)。2次及以上住院患者单一氯氮平使用频率、合并氯氮平使用频率及氯氮平使用总频率均呈下降趋势(P0.05)。3年间市、县级医院单一氯氮平使用频率均呈下降趋势(P0.05);市级医院合并氯氮平使用频率呈下降趋势(P0.05)。首次住院患者省、市、县级医院单一氯氮平使用频率均呈下降趋势(P0.05);首次住院省、市、县合并氯氮平使用频率3年间差异无统计学意义(P0.05);2次及以上住院患者市、县级医院单一氯氮平使用频率呈下降趋势(P0.05);市级医院合并氯氮平使用频率呈下降趋势(P0.05)。结论氯氮平在河北省住院精神分裂症患者中使用频率呈下降趋势;但不同级别医院首次住院合并氯氮平使用频率下降趋势不明显,应引起临床关注。
[Abstract]:Objective to investigate the trend of clozapine use during hospitalization in schizophrenia patients in Hebei Province in 2002, 2006 and 2012. Methods in 2002, 2006 and 2012, 543 patients with schizophrenia were enrolled in mental health institutions in Hebei Province, including 543 patients in 2002, 608 patients in 2006 and 2.911 patients in 2012. The use of clozapine in patients with clozapine was investigated by self-designed psychotropic substance use questionnaire. The frequency of single clozapine used in different hospitalization times and different levels of hospitals was compared, and the frequency of clozapine combined with other drugs (combined with clozapine) and the total frequency of clozapine use were compared. Results the frequency of monoclozapine, the frequency of combined clozapine and the total frequency of clozapine in inpatients with schizophrenia in 2002, 2006 and 2012 showed a downward trend (P 0.05). The frequency of monoclozapine and the total frequency of clozapine in the first inpatient showed a downward trend (P 0.05). The frequency of monoclozapine was used twice or more in inpatients. The frequency of combined clozapine use and the total frequency of clozapine use showed a downward trend (P 0.05). In 3 years, the frequency of single clozapine use in county-level hospitals showed a downward trend (P 0.05). The frequency of clozapine use in municipal hospitals showed a downward trend (P 0.05). The frequency of single clozapine use in the provinces, cities and county hospitals of the first inpatients showed a downward trend (P 0.05), but there was no significant difference in the frequency of clozapine use in the provinces, cities and counties for the first time (P 0.05). The frequency of single clozapine in county-level hospitals showed a downward trend (P 0.05), and the frequency of clozapine use in municipal hospitals decreased (P 0.05). Conclusion the frequency of clozapine use in hospitalized patients with schizophrenia in Hebei Province shows a downward trend, but the decreasing trend of clozapine usage frequency in different hospitals for the first time is not obvious, which should be paid more and more attention.
【作者单位】：河北省第六人民医院;
【基金】：河北省卫生厅医学科学研究重点课题计划(20130208)
【分类号】：R749.3

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