非痴呆型血管性认知障碍的静息态功能磁共振研究
发布时间：2019-06-10 11:37
【摘要】：【目的】 研究非痴呆型血管性认知障碍(Vascularcognitiveimpairmentnodementia,VCIND)前扣带回神经网络的异常改变及其与MOCA的相关性，探讨对VCIND的认知具有潜在临床预测价值的脑区。 【方法】 1．采用MOCA量表对14例VCIND患者（入选标准：右利手，45~80岁，小学文化及以上，MRI检查明确的皮层下缺血性脑血管病患者，北京版MOCA26分；排除标准：可能导致认知障碍的全身性疾病，可能导致认知障碍的神经疾病，抑郁症和精神病患者，有酒精或药物滥用、化学物品中毒等有可能干扰研究的疾病，有失语、视听障碍等妨碍评估进行的躯体功能缺陷）和16例健康老年人（对照组）的认知功能进行调查分析。 2．采用静息态磁共振功能连接的方法绘制所有被试的前扣带回神经网络模式特征。 3．将VCIND患者前扣带回功能连接的强度与MOCA进行相关分析。 【结果】 1．VCIND组的MoCA总分、视空间/执行功能、注意力/计算力、语言、定向力亚项显著低于正常对照组（p0.05）；抽象能力/记忆力、命名亚项在两组之间无明显统计学差异（p0.05）。 2．VCIND组前扣带回与全脑功能连接低于正常对照组的脑区有：左侧颞中回/颞上回、额上回/额中回/额下回、后扣带皮层/楔前叶、顶下小叶/角回，右侧颞中回/颞上回、眶额回/额下回、顶下小叶/角回、额上回/额中回；VCIND组前扣带回与全脑功能连接高于正常对照组的脑区有：右小脑后叶，距状裂，左额中回、左中央前回。 3．VCIND组前扣带回的功能连接强度与MOCA呈正相关的脑区：左顶下小叶、右侧颞中回、右额上回、左侧颞上回；呈负相关的脑区：右内囊后肢、左楔前叶、左颞中回、右内囊前肢。 【结论】 1．VCIND患者存在执行功能、注意力、语言等多项认知障碍。 2．VCIND患者在静息状态下表现出异常的前扣带回神经网络改变，，尤其默认网络存在明显异常。 3．左顶下小叶、右额上回等脑区与ACC的功能连接异常对VCIND的认知具有潜在的临床预测价值。
[Abstract]:[objective] to study the abnormal changes of anterior cingulate gyrus neural network in non-dementia vascular cognitive impairment (Vascularcognitiveimpairmentnodementia,VCIND) and its correlation with MOCA, and to explore the brain regions which have potential clinical predictive value for the cognition of VCIND. [methods] 1. 14 patients with VCIND were selected with MOCA scale (right hand, 45 years old, primary school culture and above, MRI score of subcortical ischemic cerebrovascular disease, Beijing version of MOCA26). Exclusion criteria: systemic diseases that may lead to cognitive impairment, neurological diseases that may lead to cognitive impairment, depression and mental illness, diseases such as alcohol or drug abuse, chemical poisoning, which may interfere with the study, and aphasia. The cognitive function of 16 healthy elderly (control group) and 16 healthy elderly (control group) were investigated and analyzed. 2. The neural network characteristics of anterior cingulate gyrus were drawn by resting magnetic resonance functional connection. 3. The intensity of anterior cingulate function connection in patients with VCIND was correlated with MOCA. [results] the total score of MoCA, visual space / executive function, attention / computational power, language and orientation subitems in 1.VCIND group were significantly lower than those in normal control group (p0.05). There was no significant difference in abstract ability / memory and naming subitems between the two groups (p0.05). The connection between anterior cingulate gyrus and whole brain function in 2.VCIND group was lower than that in normal control group: left middle temporal gyrus / superior temporal gyrus, superior frontalis / middle frontalis / inferior frontalis, posterior cingulate cortex / anterior cuneiform lobe, inferior parietal lobule / angular gyrus, right middle temporal gyrus / superior temporal gyrus. Orbital / inferior frontalis, inferior parietal lobule / angular gyrus, superior frontalis / middle frontalis; The connections between anterior cingulate gyrus and whole brain function in VCIND group were higher than those in normal control group, including posterior lobe of right cerebellum, talus, left middle forehead gyrus and left anterior central gyrus. In 3.VCIND group, the functional connection intensity of anterior cingulate gyrus was positively correlated with MOCA: left inferior parietal lobule, right middle temporal gyrus, right superior forehead gyrus, left superior temporal gyrus; There was a negative correlation between the right internal capsule hindlimb, the left anterior cuneiform lobe, the left middle temporal gyrus and the right internal capsule forelimb. [conclusion] 1.VCIND patients have many cognitive impairment, such as executive function, attention, language and so on. 2.VCIND patients showed abnormal anterior cingulate neural network changes in resting state, especially the default network was significantly abnormal. 3. The abnormal functional connection between the left inferior parietal lobule and the right superior frontal gyrus and ACC has potential clinical predictive value for the cognition of VCIND.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.1;R445.2
本文编号：2496428
[Abstract]:[objective] to study the abnormal changes of anterior cingulate gyrus neural network in non-dementia vascular cognitive impairment (Vascularcognitiveimpairmentnodementia,VCIND) and its correlation with MOCA, and to explore the brain regions which have potential clinical predictive value for the cognition of VCIND. [methods] 1. 14 patients with VCIND were selected with MOCA scale (right hand, 45 years old, primary school culture and above, MRI score of subcortical ischemic cerebrovascular disease, Beijing version of MOCA26). Exclusion criteria: systemic diseases that may lead to cognitive impairment, neurological diseases that may lead to cognitive impairment, depression and mental illness, diseases such as alcohol or drug abuse, chemical poisoning, which may interfere with the study, and aphasia. The cognitive function of 16 healthy elderly (control group) and 16 healthy elderly (control group) were investigated and analyzed. 2. The neural network characteristics of anterior cingulate gyrus were drawn by resting magnetic resonance functional connection. 3. The intensity of anterior cingulate function connection in patients with VCIND was correlated with MOCA. [results] the total score of MoCA, visual space / executive function, attention / computational power, language and orientation subitems in 1.VCIND group were significantly lower than those in normal control group (p0.05). There was no significant difference in abstract ability / memory and naming subitems between the two groups (p0.05). The connection between anterior cingulate gyrus and whole brain function in 2.VCIND group was lower than that in normal control group: left middle temporal gyrus / superior temporal gyrus, superior frontalis / middle frontalis / inferior frontalis, posterior cingulate cortex / anterior cuneiform lobe, inferior parietal lobule / angular gyrus, right middle temporal gyrus / superior temporal gyrus. Orbital / inferior frontalis, inferior parietal lobule / angular gyrus, superior frontalis / middle frontalis; The connections between anterior cingulate gyrus and whole brain function in VCIND group were higher than those in normal control group, including posterior lobe of right cerebellum, talus, left middle forehead gyrus and left anterior central gyrus. In 3.VCIND group, the functional connection intensity of anterior cingulate gyrus was positively correlated with MOCA: left inferior parietal lobule, right middle temporal gyrus, right superior forehead gyrus, left superior temporal gyrus; There was a negative correlation between the right internal capsule hindlimb, the left anterior cuneiform lobe, the left middle temporal gyrus and the right internal capsule forelimb. [conclusion] 1.VCIND patients have many cognitive impairment, such as executive function, attention, language and so on. 2.VCIND patients showed abnormal anterior cingulate neural network changes in resting state, especially the default network was significantly abnormal. 3. The abnormal functional connection between the left inferior parietal lobule and the right superior frontal gyrus and ACC has potential clinical predictive value for the cognition of VCIND.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.1;R445.2
【参考文献】
相关期刊论文 前3条
1 李心天;中国人的左右利手分布[J];心理学报;1983年03期
2 中国防治认知功能障碍专家共识专家组;;中国防治认知功能障碍专家共识[J];中华内科杂志;2006年02期
3 贾建平;重视血管性认知障碍的早期诊断和干预[J];中华神经科杂志;2005年01期
本文编号：2496428
本文链接：https://www.wllwen.com/yixuelunwen/jsb/2496428.html
最近更新
教材专著
