益智开窍针刺疗法联合言语训练治疗儿童语言发育迟缓90例临床观察

发布时间：2019-06-15 00:10

【摘要】：目的观察益智开窍针刺疗法联合言语训练治疗儿童语言发育迟缓的疗效及对患儿血清中神经生长因子(NGF)、脑源性神经营养因子(BDNF)、胶质细胞源性神经营养因子(GDNF)和睫状神经营养因子(CNTF)水平的影响。方法将郑州大学第三附属医院收治的语言发育迟缓患儿90例作为研究对象,采用随机数字表法分为对照组和治疗组各45例。对照组采取经颅磁刺激疗法。治疗组采取益智开窍针刺疗法联合言语训练治疗。比较两组言语功能评分、Gesell发育量表语言发育商(DQ)评分及临床疗效。检测两组血清中NGF、BDNF、GDNF和CNTF水平。结果治疗后,治疗组言语功能相关指标评分和Gesell发育量表各指标分值显著高于对照组(P0.01)。治疗组的总有效率为95.45%,显著优于对照组的76.47%(P0.05)。治疗后,治疗组患者血清中NGF、BDNF、GDNF和CNTF水平显著提高,且显著高于对照组,差异有统计学意义(P0.01)。结论益智开窍针刺疗法联合言语训练治疗儿童语言发育迟缓疗效明显,能显著提高患儿体内NGF、BDNF、GDNF和CNTF水平。
[Abstract]:Objective to observe the effect of Yizhi Kaiqiao acupuncture combined with speech training on children with language retardation and its effect on the levels of glial cell-derived neurotrophic factor (GDNF) and ciliary neurotrophic factor (CNTF) in serum of children with (NGF), brain-derived neurotrophic factor (BDNF),. Methods 90 children with language retardation admitted to the third affiliated Hospital of Zhengzhou University were randomly divided into control group (n = 45) and treatment group (n = 45). The control group was treated with transcranial magnetic stimulation. The treatment group was treated with Yizhi Kaiqiao acupuncture combined with speech training. The speech function score, Gesell development scale language development quotient (DQ) score and clinical efficacy were compared between the two groups. The levels of NGF,BDNF,GDNF and CNTF in serum of the two groups were measured. Results after treatment, the scores of speech function related indexes and Gesell development scale in the treatment group were significantly higher than those in the control group (P 0.01). The total effective rate of the treatment group was 95.45%, which was significantly better than that of the control group (76.47%) (P 0.05). After treatment, the levels of serum NGF,BDNF,GDNF and CNTF in the treatment group were significantly higher than those in the control group (P 0.01). Conclusion Yizhi Kaiqiao acupuncture combined with speech training is effective in the treatment of language retardation in children, and can significantly increase the levels of NGF,BDNF,GDNF and CNTF in children.
【作者单位】：郑州大学第三附属医院;河南中医药大学第三附属医院;
【分类号】：R749.94

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