甲基苯丙胺成瘾机制进展

发布时间：2019-06-15 08:01

【摘要】：甲基苯丙胺(methamphetamine,MA)属于苯丙胺类中枢兴奋剂(amphetamine-type stimulants,ATS)。MA和阿片类传统毒品相比,最大的区别在于其强烈的精神成瘾性,且具有复吸率高、易获得、躯体戒断症状不明显等特点,且其成瘾神经机制非常复杂,涉及多个脑区、多种神经递质及多条神经通路,与多种基因以及自噬等密切相关。探索MA成瘾的神经机制,为其预防和治疗提供思路和方法已刻不容缓。本文就MA成瘾机制的最新研究进展做一综述。
[Abstract]:Methamphetamine (methamphetamine,MA) belongs to amphetamine type central stimulant (amphetamine-type stimulants,ATS). MA). Compared with opioid traditional drugs, the biggest difference lies in its strong mental addiction, high repetition rate, easy to obtain, somatic withdrawal symptoms and other characteristics, and its addictive neural mechanism is very complex, involving multiple brain regions, multiple neurotransmitters and multiple nerve pathways. It is closely related to many genes and autophagy. It is urgent to explore the neural mechanism of MA addiction and provide ideas and methods for its prevention and treatment. In this paper, the latest research progress of MA addiction mechanism is reviewed.
【作者单位】：北京大学药学院分子与细胞药理学系;北京大学天然药物及仿生药物国家重点实验室;
【基金】：国家自然基金面上项目(81571354)
【分类号】：R749.6

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