乌灵胶囊辅助治疗对卒中后抑郁一级预防作用的临床观察
发布时间：2019-07-06 21:22
【摘要】：目的观察乌灵胶囊对卒中后抑郁(post-stroke depression,PSD)的一级预防作用。方法将急性脑卒中患者,采用随机化方法分两组。两组在心脑血管病治疗相同基础上,试验组(55例)加服乌灵胶囊(每粒0.33 g)每次3粒,1日3次;对照组55例,加服安慰剂每次3粒,1日3次;2周为1个疗程。每2周进行PSD诊断,符合PSD停服药物;不符合PSD继续服药;持续服药1~12个疗程(共计6个月),若仍不符合PSD,则停止服药。观察PSD发病率、出现抑郁的时间、汉密尔顿抑郁量表(HAMD)评分及不良反应。结果试验组PSD发病率1、3、6个月时分别为8%、16%和34%,对照组分别为19.6%、29.4%和54.9%,试验组发生率均低于对照组,且6个月时比较,差异有统计学意义(χ2=4.465,P0.05)。试验组发生PSD平均时间为(14.96±8.31)周,对照组为(9.36±6.06)周,两组比较,差异有统计学意义(t=6.762,P0.05);随访6个月,试验组发生PSD时的HAMD评分为(11.96±2.14)分,对照组为(14.57±4.24)分,两组比较,差异有统计学意义(t=5.641,P0.05)。结论乌灵胶囊在降低PSD发病率、延缓PSD发生时间、减轻PSD发生抑郁程度方面均优于安慰剂组,对PSD有一定的预防作用。
[Abstract]:Objective to observe the primary preventive effect of Wuling capsule on post-stroke depression (post-stroke depression,PSD). Methods the patients with acute stroke were randomly divided into two groups. On the basis of the same treatment of cardiovascular and cerebrovascular diseases, the experimental group (55 cases) was treated with Wuling capsule (0.33 g each) 3 times a day, while the control group (55 cases) was treated with placebo 3 tablets at a time, 3 times a day, and 2 weeks as a course of treatment. PSD diagnosis was performed every 2 weeks, which was in accordance with PSD withdrawal, non-compliance with PSD and 12 courses of treatment (total 6 months). If not in accordance with PSD, the drug was stopped. The incidence of PSD, the time of depression, Hamilton depression scale (HAMD) score and adverse reactions were observed. Results the incidence of PSD in the experimental group was 1, 3, 8%, 16% and 34% at 6 months, and 19.6%, 29.4% and 54.9% in the control group, respectively. the incidence rate in the experimental group was lower than that in the control group, and the difference was statistically significant at 6 months (蠂 2 鈮，
本文编号：2511338
[Abstract]:Objective to observe the primary preventive effect of Wuling capsule on post-stroke depression (post-stroke depression,PSD). Methods the patients with acute stroke were randomly divided into two groups. On the basis of the same treatment of cardiovascular and cerebrovascular diseases, the experimental group (55 cases) was treated with Wuling capsule (0.33 g each) 3 times a day, while the control group (55 cases) was treated with placebo 3 tablets at a time, 3 times a day, and 2 weeks as a course of treatment. PSD diagnosis was performed every 2 weeks, which was in accordance with PSD withdrawal, non-compliance with PSD and 12 courses of treatment (total 6 months). If not in accordance with PSD, the drug was stopped. The incidence of PSD, the time of depression, Hamilton depression scale (HAMD) score and adverse reactions were observed. Results the incidence of PSD in the experimental group was 1, 3, 8%, 16% and 34% at 6 months, and 19.6%, 29.4% and 54.9% in the control group, respectively. the incidence rate in the experimental group was lower than that in the control group, and the difference was statistically significant at 6 months (蠂 2 鈮，
本文编号：2511338
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