未用药精神分裂症患者睡眠结构的meta分析

发布时间：2019-07-07 07:40

【摘要】：目的:系统分析未用药精神分裂症患者与正常对照相比睡眠结构的特征性改变。方法:使用关键词"精神分裂症"和"睡眠结构"(或"睡眠紊乱"或"多导睡眠图"等)在MEDLINE、Embase、Springer、PsychINFO、谷歌学术、万方数据库等检索相关文献,发表时间为1980年-2015年,筛选针对未用药精神分裂症患者睡眠结构特点的对照研究,最终共纳入15篇文献,使用文献质量评价量表(NOS)评价纳入研究的文献质量。用Stata13.0软件完成meta统计分析。结果:未用药精神分裂症患者与健康对照相比,总睡眠时间减少,睡眠潜伏期延长(P0.01),睡眠效率下降,快动眼睡眠潜伏期缩短(均P0.01)。未用药精神分裂症患者的非快动眼1期睡眠所占比例增加,4期和慢波睡眠期所占比例减少,差异有统计学意义。结论:在排除药物的影响下,精神分裂症患者的睡眠质量明显低于正常对照,表现为总睡眠时间减少(以慢波睡眠减少为著),睡眠潜伏期延长,睡眠效率下降等。
文内图片：

图片说明：监测指标为总睡眠时间、睡眠潜伏期、睡眠效率、REM潜伏期的meta分析结果
[Abstract]:Objective: to systematically analyze the characteristic changes of sleep structure in patients with schizophrenia without medication compared with normal controls. Methods: the key words "schizophrenia" and "sleep structure" (or "sleep disorder" or "polysomnography", etc.) were used to search the relevant literature in MEDLINE,Embase,Springer,PsychINFO, Google academic, Wanfang Database, etc., published from 1980 to 2015. A comparative study on the characteristics of sleep structure of patients with schizophrenia without medication was screened and finally included in 15 articles. The literature quality included in the study was evaluated by using the document quality Evaluation scale (NOS). Meta statistical analysis is completed with Stata13.0 software. Results: compared with the healthy control group, the total sleep time, sleep latency, sleep efficiency and fast eye movement sleep latency of the patients with schizophrenia were decreased (P 0.01), and that of the control group was significantly lower than that of the control group (P 0.01). The proportion of non-fast eye movement stage 1 sleep in patients with schizophrenia without medication increased, while the proportion of stage 4 and slow wave sleep decreased, the difference was statistically significant. Conclusion: under the influence of excluding drugs, the sleep quality of patients with schizophrenia is significantly lower than that of the normal control, which is characterized by the decrease of total sleep time (especially the decrease of slow wave sleep), the prolongation of sleep latency and the decrease of sleep efficiency.
【作者单位】：北京回龙观医院;北京大学第六医院北京大学精神卫生研究所卫生部精神卫生学重点实验室(北京大学);
【基金】：国家重点基础研究发展计划(973计划)-睡眠对认知调节的神经影像学机制(2015CB856404) 北京市自然科学基金-左利手遗传素质及后天转换对精神分裂症流行病学的影响(7254208)
【分类号】：R749.3

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