巴戟天寡糖对抑郁症患者血浆BDNF,GDNF,VEGF和IGF-1水平的影响
发布时间：2019-07-12 07:59
【摘要】：目的:了解巴戟天寡糖对抑郁症患者血浆脑源性神经营养因子(BDNF)、胶质源性神经营养因子(GDNF)、血管内皮生长因子(VEGF)和胰岛素样生长因子(IGF-1)浓度的影响,探讨巴戟天寡糖治疗抑郁症前后BDNF,GDNF,VEGF和IGF-1的浓度变化与其疗效的关系。方法:本研究入组符合ICD-10的轻中度抑郁症门诊患者32例。入组后单一巴戟天抗抑郁治疗,每2周访视1次,记录患者的抑郁症状及服药情况,共治疗8周,入组前后各采血1次,采用酶联免疫吸附法测定患者血浆BDNF,GDNF,VEGF和IGF-1水平,同时以汉密尔顿抑郁量表(HAMD-17)评定患者的抑郁程度。结果:巴戟天寡糖抗抑郁治疗8周后,HAMD-17总分及各因子分显著降低(P0.01);巴戟天寡糖治疗8周后,VEGF水平显著下降(Z=-2.354,P0.05),BDNF和GDNF水平显著上升(Z=-4.157,P0.01;Z=-4.345,P0.01),而治疗前后IGF-1水平没有显著变化(Z=-0.901,P0.05);治疗前后BDNF和GDNF浓度变化率与HAMD-17减分率呈正相关,其相关系数(r)分别为0.782(P0.01)和0.456(P0.05),而VEGF与IGF-1浓度变化率与HAMD-17减分率无关(分别为r=0.06,P0.05;r=0.039,P0.05)。结论:巴戟天寡糖可以改善BDNF,GDNF和VEGF的异常水平,但对IGF-1水平没有影响。
[Abstract]:Objective: to investigate the effect of Morinda officinalis oligosaccharide on plasma levels of brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), (VEGF) and insulin-like growth factor (IGF-1) in patients with depression, and to explore the relationship between the concentration of BDNF,GDNF,VEGF and IGF-1 and the curative effect of Morinda officinalis oligosaccharide before and after treatment of depression. Methods: 32 outpatients with mild to moderate depression in accordance with ICD-10 were enrolled in this study. After admission, the antidepressant therapy of Euphorbia pulcherrima was followed up every 2 weeks. The depressive symptoms and medication were recorded for 8 weeks. Blood samples were collected once before and after admission to the group. The plasma BDNF,GDNF,VEGF and IGF-1 levels were measured by enzyme-linked immunosorbent assay (Elisa). At the same time, the depression degree of the patients was evaluated by Hamilton depression scale (HAMD-17). Results: after 8 weeks of antidepressant treatment, the total score of HAMD-17 and the scores of each factor decreased significantly (P 0.01), and after 8 weeks of treatment, the level of VEGF decreased significantly (Z 鈮，
本文编号：2513573
[Abstract]:Objective: to investigate the effect of Morinda officinalis oligosaccharide on plasma levels of brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), (VEGF) and insulin-like growth factor (IGF-1) in patients with depression, and to explore the relationship between the concentration of BDNF,GDNF,VEGF and IGF-1 and the curative effect of Morinda officinalis oligosaccharide before and after treatment of depression. Methods: 32 outpatients with mild to moderate depression in accordance with ICD-10 were enrolled in this study. After admission, the antidepressant therapy of Euphorbia pulcherrima was followed up every 2 weeks. The depressive symptoms and medication were recorded for 8 weeks. Blood samples were collected once before and after admission to the group. The plasma BDNF,GDNF,VEGF and IGF-1 levels were measured by enzyme-linked immunosorbent assay (Elisa). At the same time, the depression degree of the patients was evaluated by Hamilton depression scale (HAMD-17). Results: after 8 weeks of antidepressant treatment, the total score of HAMD-17 and the scores of each factor decreased significantly (P 0.01), and after 8 weeks of treatment, the level of VEGF decreased significantly (Z 鈮，
本文编号：2513573
本文链接：https://www.wllwen.com/yixuelunwen/jsb/2513573.html
最近更新
教材专著
