路易体痴呆临床特点分析

发布时间：2019-08-05 16:34

【摘要】：目的研究路易体痴呆(dementia with lewy body,DLB)的临床特点、诊断要点、治疗及预后,以期全面提高对本病的认识及诊治水平。方法研究我院收治临床诊断DLB患者13例,分析临床表现、专科查体、辅助检查、治疗以及预后。结果 13例患者均出现进行性痴呆,部分有波动,11例诊断为很可能DLB,2例诊断为可能DLB。所有患者中伴有波动性认知障碍8例(8/13)、帕金森综合征8例(8/13)、视幻觉8例(8/13)、记忆力减退13例(13/13)、肢体震颤4例(4/13)、谵妄状态5例(5/13)、睡眠增多3例(3/13)、缄默1例(1/13)、焦虑抑郁状态9例(9/13)、头晕1例(1/13)、快动眼睡眠期行为异常6例(6/13)、对地西泮异常敏感1例(1/13)。随访6个月~5年,患者认知功能波动,总体病情进展,其中2例死亡。结论路易体痴呆是不可逆进行性加重的神经变性疾病,早期全面的认识其临床特点,有利于避免本病延误诊治,进一步改善预后。
[Abstract]:Objective To study the clinical features, diagnosis points, treatment and prognosis of the dementia with lewy body (DLB) in order to improve the understanding of the disease and the level of diagnosis and treatment. Methods 13 cases of DLB were treated in our hospital, and the clinical manifestation, the special examination, the auxiliary examination, the treatment and the prognosis were analyzed. Results All 13 patients had progressive dementia, some of them had fluctuation,11 cases were diagnosed as DLB, and 2 cases were diagnosed as possible DLB. There were 8 cases (8/13),8 (8/13),8 (8/13),13 (13/13),4 (4/13),5 (5/13),3 (3/13) and 1 (1/13). There were 9 cases (9/13),1 (1/13),6 (6/13), and 1 (1/13) of anxiety and depression. Follow-up for 6 months to 5 years, the patient's cognitive function was fluctuating, and the overall condition progressed, of which 2 cases died. Conclusion Lewy body dementia is an irreversible and progressive neurodegenerative disease, and the early and comprehensive understanding of its clinical characteristics is beneficial to avoiding the delay and treatment of this disease and further improving the prognosis.
【作者单位】：第四军医大学西京医院神经内科;陕西省人民医院神内一科;
【基金】：国家自然科学基金(编号:81371365)
【分类号】：R749.16

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