临床颈部淋巴结阴性舌鳞癌中肿瘤转移相关因子1的表达及与病理分级的关系

发布时间：2017-12-31 15:37

  本文关键词：临床颈部淋巴结阴性舌鳞癌中肿瘤转移相关因子1的表达及与病理分级的关系　出处：《广东医学》2016年10期 　论文类型：期刊论文

  更多相关文章： 舌鳞状细胞癌 MTA蛋白 量子点荧光探针

【摘要】：目的应用量子点荧光探针检测临床颈部淋巴结阴性(c N0)舌鳞癌组织中肿瘤转移相关因子1(MTA1)蛋白的表达强度,探讨MTA1的表达与舌鳞癌组织病理分级的相关性。方法量子点荧光探针及免疫组化染色法检测48例舌鳞癌标本MTA1在鳞癌组织及癌周围正常组织中的表达,同时按照组织病理分级分组比较各组间MTA1蛋白表达强度的差异。结果量子点荧光探针检测MTA1蛋白在高分化(Ⅰ级)、中分化(Ⅱ级)及低分化(Ⅲ级)组中的阳性表达率分别为42.1%、73.3%、85.7%,各组间差异有统计学意义(P0.05);免疫组化染色检测MTA1蛋白在3组中的阳性表达率分别为36.8%、66.7%、78.6%,各组间差异有统计学意义(P0.05),即分化程度越低,其阳性表达率越高。结论 MTA1蛋白表达强度与c N_0舌鳞癌病理分化程度关系密切,MTA1蛋白可能在c N0舌鳞癌的局部浸润生长中起重要作用。
[Abstract]:Objective to detect the expression of tumor metastasis associated factor 1 (MTA1) protein in cervical lymph node negative tongue squamous cell carcinoma (LSCC) by using quantum dot fluorescence probe (QDFS). To investigate the correlation between the expression of MTA1 and the pathological grade of tongue squamous cell carcinoma. Methods the expression of MTA1 in 48 cases of tongue squamous cell carcinoma and its surrounding normal tissues were detected by quantum dot fluorescence probe and immunohistochemical staining. Expression. At the same time, the expression intensity of MTA1 protein was compared according to histopathological grading. Results Quantum Dot fluorescence probe was used to detect the expression of MTA1 protein in high differentiation (grade 鈪，

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