维吾尔族口腔鳞状细胞癌患者中血清鳞状细胞癌抗原的表达研究

发布时间：2018-01-02 07:29

本文关键词：维吾尔族口腔鳞状细胞癌患者中血清鳞状细胞癌抗原的表达研究　出处：《国际口腔医学杂志》2016年06期 　论文类型：期刊论文

【摘要】：目的探讨维吾尔族口腔鳞状细胞癌(OSCC)患者血清中鳞状细胞癌抗原(SCC-Ag)的表达。方法采用化学发光法检测90例维吾尔族OSCC患者(OSCC组)和90例维吾尔族其他口腔恶性肿瘤患者(口腔非OSCC恶性肿瘤组)、101例维吾尔族口腔良性肿瘤患者(良性肿瘤组)和120例维吾尔族正常对照者(正常组)的血清SCC-Ag水平,并对其中60例OSCC和60例口腔非OSCC恶性肿瘤患者治疗前后SCC-Ag水平进行检测,分析SCC-Ag在OSCC诊断、治疗疗效中的意义。结果OSCC组的SCC-Ag水平明显高于口腔非OSCC恶性肿瘤组(P=0.002),良性肿瘤组(P=0.001)和正常组(P=0.001)。OSCC患者血清SCC-Ag阳性串为43.3%(39/90),明显高于其他3组(P=0.0001)。OSCC患者TNM晚期的术前SCC-Ag水平的表达高于早期水平(P0.05)。复发组和未复发组的术前、术后、放化疗后SCC-Ag水平相比较,差异均有统计学意义(P0.05)。手术及放化疗前后鳞状细胞癌患者血清SCC-Ag水平变化差异有统计学意义(P0.01),然而,在口腔非OSCC恶性肿瘤组治疗疗效差异无统计学意义(P0.05)。结论血清SCC-Ag对维吾尔族OSCC患者的早期诊断敏感性不高,但在评价治疗疗效,预测肿瘤复发方面有重要的临床意义。
[Abstract]:Objective to investigate the expression of squamous cell carcinoma antigen (SCC-Ag) in the serum of Uygur oral squamous cell carcinoma (OSCC) patients. OSCC group) and 90 cases of other Uygur oral malignant tumors (oral non-#en1# malignant tumor group). Serum SCC-Ag levels were measured in 101 patients with oral benign tumor (benign tumor group) and 120 normal controls (normal group). The levels of SCC-Ag in 60 cases of OSCC and 60 cases of non-#en1# malignant tumor of oral cavity were detected before and after treatment, and the diagnosis of SCC-Ag in OSCC was analyzed. Results the level of SCC-Ag in OSCC group was significantly higher than that in oral non-#en2# malignant tumor group (P 0.002). The serum SCC-Ag positive sequence in benign tumor group and normal group was 43.3% 39 / 90). The expression of SCC-Ag in the late stage of TNM was significantly higher than that in the other three groups. The expression of SCC-Ag in the late stage of TNM was higher than that in the early stage (P 0.05). Postoperative SCC-Ag levels were compared after radiotherapy and chemotherapy. There were significant differences in serum SCC-Ag levels before and after operation and radiotherapy and chemotherapy in patients with squamous cell carcinoma (P 0.05). However, there was a significant difference in serum SCC-Ag level between patients with squamous cell carcinoma before and after operation. There was no significant difference in the curative effect in oral non-#en0# malignant tumor group (P 0.05). Conclusion the early diagnostic sensitivity of serum SCC-Ag in Uygur patients with OSCC is not high. But it has important clinical significance in evaluating therapeutic effect and predicting tumor recurrence.
【作者单位】：新疆维吾尔自治区人民医院颌面外科;北京大学口腔医院口腔颌面外科;上海交通大学医学院附属第九人民医院口腔颌面外科;
【基金】：中华口腔医学会西部行口腔医学临床科研基金(CSA-W-2014-2)~~
【分类号】：R739.85
【正文快照】： 头颈部恶性肿瘤在全世界范围内的发病率较高,口腔癌位居全身恶性肿瘤的第六位。中国口腔颌面部恶性肿瘤为全身恶性肿瘤的8.2%,其中,口腔鳞状细胞癌(oral squamous cell carci-noma,OSCC)是口腔颌面部恶性肿瘤中最多见的类型,约占80%以上[1]。在新疆,维吾尔族口腔颌面部恶性肿

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